Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.
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Voltage-gated sodium channels and cancer: is excitability their primary role?Inherited bradyarrhythmia: A diverse genetic backgroundThe genetic background of arrhythmogenic right ventricular cardiomyopathySCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmiaFocal treatment for genetic disorders (a fairy tale or a true story?).Whole-exome sequencing identifies Y1495X of SCN5A to be associated with familial conduction disease and sudden death.Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disordersA truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation.The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunctionAngiotensin II Induced Cardiac Dysfunction on a Chip.Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.Rare Variants in Cardiomyopathy Genes Associated With Stress-Induced CardiomyopathyCardiac sodium channel mutations: why so many phenotypes?Identifying potential functional impact of mutations and polymorphisms: linking heart failure, increased risk of arrhythmias and sudden cardiac deathBrugada syndrome in children.Broad-based molecular autopsy: a potential tool to investigate the involvement of subtle cardiac conditions in sudden unexpected death in infancy and early childhood.Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade.Evaluation and management of bradycardia in neonates and children.Distinguishing pathogenic mutations from background genetic noise in cardiology: the use of large genome databases for genetic interpretation.Sodium channels in astroglia and microglia.Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations.Analysis of SCN5A Gene Variants in East Slovak Patients with Cardiomyopathy.Familial long QT syndrome and late development of dilated cardiomyopathy in a child with a KCNQ1 mutation: A case report.Arrhythmia: 100 years on from George Ralph Mines.Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome.Cardiac Arrhythmias Related to Sodium Channel Dysfunction.Infant sudden death: Mutations responsible for impaired Nav1.5 channel trafficking and function.A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations.Inhibitory effects of neferine on Nav1.5 channels expressed in HEK293 cells.Disease Modifiers of Inherited ChannelopathyElectrocardiogram changes and atrial arrhythmias in individuals carrying sodium channel SCN5A D1275N mutationVariants: Association With Cardiac DisordersMexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patientsBrugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels
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Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.
description
article científic
@ca
article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
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name
Cardiac sodium channelopathy a ...... molecular and genetic aspects.
@en
type
label
Cardiac sodium channelopathy a ...... molecular and genetic aspects.
@en
prefLabel
Cardiac sodium channelopathy a ...... molecular and genetic aspects.
@en
P2860
P1476
Cardiac sodium channelopathy a ...... molecular and genetic aspects.
@en
P2093
Carol Ann Remme
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P304
P356
10.1113/JPHYSIOL.2013.256461
P407
P577
2013-07-01T00:00:00Z