Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
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Novel drugs that target the metabolic reprogramming in renal cell cancerOncometabolites: Unconventional triggers of oncogenic signalling cascadesThe Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells.Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers.CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.Arginine dependence of tumor cells: targeting a chink in cancer's armor.Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.Mutations in the Human Argininosuccinate Synthetase (ASS1) Gene, Impact on Patients, Common Changes, and Structural Considerations.Targeting amino acid metabolism for cancer therapy.Understanding the Intersections between Metabolism and Cancer Biology.Metabolic reprogramming in clear cell renal cell carcinoma.The interplay between metabolic remodeling and immune regulation in glioblastoma.Monitoring amino acid deficiencies in cancerInhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.A metabolic link between the urea cycle and cancer cell proliferation.Optimizing arginine deprivation for hard-to-treat cancers.Targeting Metabolism for Cancer Therapy.Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.DNA Damage, Repair, and Cancer Metabolism.Metabolomics and Metabolic Reprogramming in Kidney Cancer.Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.Aspartate is an endogenous metabolic limitation for tumour growthThe big picture: exploring the metabolic cross-talk in cancerArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunctionSensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle EnzymesArginine and the metabolic regulation of nitric oxide synthesis in cancer
P2860
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P2860
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
@en
type
label
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
@en
prefLabel
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
@en
P2093
P2860
P50
P356
P1433
P1476
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
@en
P2093
Alexander Brandis
Alon Silberman
Alona Sarver
Ayelet Erez
Eytan Ruppin
Igor Ulitsky
Keren Yizhak
Lital Adler
Noa Stettner
Sandesh Cs Nagamani
P2860
P2888
P304
P356
10.1038/NATURE15529
P407
P577
2015-11-11T00:00:00Z
P6179
1001151665