Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. - Wikidata - wikimedia - TriplyDB

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

http://www.wikidata.org/entity/Q38820081

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Novel drugs that target the metabolic reprogramming in renal cell cancer Oncometabolites: Unconventional triggers of oncogenic signalling cascades The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells.Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers.CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.Arginine dependence of tumor cells: targeting a chink in cancer's armor.Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.Mutations in the Human Argininosuccinate Synthetase (ASS1) Gene, Impact on Patients, Common Changes, and Structural Considerations.Targeting amino acid metabolism for cancer therapy.Understanding the Intersections between Metabolism and Cancer Biology.Metabolic reprogramming in clear cell renal cell carcinoma.The interplay between metabolic remodeling and immune regulation in glioblastoma.Monitoring amino acid deficiencies in cancer Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.A metabolic link between the urea cycle and cancer cell proliferation.Optimizing arginine deprivation for hard-to-treat cancers.Targeting Metabolism for Cancer Therapy.Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.DNA Damage, Repair, and Cancer Metabolism.Metabolomics and Metabolic Reprogramming in Kidney Cancer.Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.Aspartate is an endogenous metabolic limitation for tumour growth The big picture: exploring the metabolic cross-talk in cancer Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes Arginine and the metabolic regulation of nitric oxide synthesis in cancer

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P2860

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

http://www.wikidata.org/entity/Q38820081

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

@en

type

label

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

@en

prefLabel

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

@en

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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

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Alexander Brandis

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Alon Silberman

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Alona Sarver

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Ayelet Erez

http://www.w3.org/2001/XMLSchema#string

Eytan Ruppin

http://www.w3.org/2001/XMLSchema#string

Igor Ulitsky

http://www.w3.org/2001/XMLSchema#string

Keren Yizhak

http://www.w3.org/2001/XMLSchema#string

Lital Adler

http://www.w3.org/2001/XMLSchema#string

Noa Stettner

http://www.w3.org/2001/XMLSchema#string

Sandesh Cs Nagamani

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P2860

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation

Global reconstruction of the human metabolic network based on genomic and bibliomic data

Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery

Integrative genome comparison of primary and metastatic melanomas.

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer.

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma.

Hepatic adaptation compensates inactivation of intestinal arginine biosynthesis in suckling mice

Recent advances in arginine metabolism: roles and regulation of the arginases.

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10.1038/NATURE15529

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7578

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527

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Daniel Helbling

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2015-11-11T00:00:00Z

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1001151665

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26560030

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4655447

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