rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.
about
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingEarly nucleolar disorganization in Dictyostelium cell death.Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell populationThe Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells.Targeting MYC in cancer therapy: RNA processing offers new opportunities.CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcomaMolecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells.The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumoursAdvanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options.Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells.BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cellsConserved nucleolar stress at the onset of cell death.Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery.Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways.Human Ribosomal RNA-Derived Resident MicroRNAs as the Transmitter of Information upon the Cytoplasmic Cancer Stress.Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why.A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network
P2860
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P2860
rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
rRNA synthesis inhibitor, CX-5 ...... 2 phase and induces apoptosis.
@en
type
label
rRNA synthesis inhibitor, CX-5 ...... 2 phase and induces apoptosis.
@en
prefLabel
rRNA synthesis inhibitor, CX-5 ...... 2 phase and induces apoptosis.
@en
P2860
P356
P1433
P1476
rRNA synthesis inhibitor, CX-5 ...... 2 phase and induces apoptosis.
@en
P2093
Patrick Brown
Sandeep S Negi
P2860
P304
18094-18104
P356
10.18632/ONCOTARGET.4093
P407
P577
2015-06-05T00:00:00Z