Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins.
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Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activityStructural determinants involved in the formation and activation of G protein betagamma dimers.Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly.Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulationInhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cellsIn vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cellsBinding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry.Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia.Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis.Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.Rapid modification of proteins using a rapamycin-inducible tobacco etch virus protease systemRegulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.Differentiation of human T cells alters their repertoire of G protein alpha-subunits.Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2)Skin phototype: a new perspective.A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signalsPDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsGbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the GolgiThe experimental power of FR900359 to study Gq-regulated biological processes.HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signalingRgs5 targeting leads to chronic low blood pressure and a lean body habitus.Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis linesInhibition of Gαs/cAMP Signaling Decreases TCR-Stimulated IL-2 transcription in CD4(+) T Helper Cells.Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4(+) T Helper Cells.Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNAMinimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimerThe role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexesRic-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane associationNegative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of DishevelledKir3 channel ontogeny - the role of Gβγ subunits in channel assembly and trafficking.Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers.Probing heterotrimeric G protein activation: applications to biased ligands.Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Gaq proteins: molecular pharmacology and therapeutic potential.
P2860
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P2860
Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
@zh-hant
name
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@en
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@nl
type
label
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@en
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@nl
prefLabel
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@en
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@nl
P2860
P356
P1476
Targeted knockdown of G protei ...... n-targeted signaling proteins.
@en
P2093
Andrejs M Krumins
P2860
P304
10250-10262
P356
10.1074/JBC.M511551200
P407
P577
2006-01-30T00:00:00Z