Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction.
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A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional terminationAn interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineriesIntrons: The Functional Benefits of Introns in GenomesFormation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesisRegulation of the processing of glucose-6-phosphate dehydrogenase mRNA by nutritional status.Splice-site mutations cause Rrp6-mediated nuclear retention of the unspliced RNAs and transcriptional down-regulation of the splicing-defective genes.Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.Identification of introns harboring functional sequence elements through positional conservation.A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cellsPosition-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNPPosition and sequence requirements for poly(A) length regulation by the poly(A) limiting element.Quality control of gene expression in the nucleus.Pre-mRNA splicing is a determinant of histone H3K36 methylationThe human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells.The function of introns.Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA.In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia.Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing.Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathwaysModeling oculopharyngeal muscular dystrophy in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 proteinLong-term and efficient expression of human β-globin gene in a hematopoietic cell line using a new site-specific integrating non-viral system.In vitro and in vivo analysis of expression cassettes designed for vascular gene transfer.Inefficient processing impairs release of RNA from the site of transcription.A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage.In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei.Inhibition of the splicing of glucose-6-phosphate dehydrogenase precursor mRNA by polyunsaturated fatty acids.Thalassaemia mutations within the 5'UTR of the human beta-globin gene disrupt transcription.Murine MHC class II locus control region drives expression of human beta-glucocerebrosidase in antigen presenting cells of transgenic mice.A systematic study of the function of the human beta-globin introns on the expression of the human coagulation factor IX in cultured Chinese hamster ovary cells.Length increase of the human alpha -globin 3'-untranslated region disrupts stability of the pre-mRNA but not that of the mature mRNA.A comparison of intrauterine hemopoietic cell transplantation and lentiviral gene transfer for the correction of severe β-thalassemia in a HbbTh3/+ murine model.
P2860
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P2860
Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@en
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@nl
type
label
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@en
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@nl
prefLabel
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@en
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@nl
P2093
P2860
P356
P1476
Efficient 3'-end formation of ...... ntly of the splicing reaction.
@en
P2093
P2860
P304
P356
10.1093/NAR/26.3.721
P407
P577
1998-02-01T00:00:00Z