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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasisHuman acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domainsCholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolismCellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteinsBinding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation.Human ACAT1 gene expression and its involvement in the development of atherosclerosis.Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells.Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells.Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.Translocation of both lysosomal LDL-derived cholesterol and plasma membrane cholesterol to the endoplasmic reticulum for esterification may require common cellular factors involved in cholesterol egress from the acidic compartments (lysosomes/endosoHigh-efficiency stable gene transfection using chloroquine-treated Chinese hamster ovary cells.Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy.Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzyme's quaternary structure and catalytic efficiency.Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice.Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol.A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene.Adenovirus expressing an NPC1-GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease.Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol.Roles of endogenously synthesized sterols in the endocytic pathway.Fate of Endogenously Synthesized Cholesterol in Niemann-Pick Type C1 CellsA simple and efficient procedure for the rapid homogenization of cultured animal cells grown in monolayerImmunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in MacrophagesSomatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-depedent regulation of cholesterol metabolismPreparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine
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description
Professor of Biochemistry at Dartmouth College Geisel School of Medicine, United States
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biochemicus
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name
Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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prefLabel
Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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Ta-Yuan Chang
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P1006
P214
P244
P1006
P1153
55663155300
P213
0000 0000 3309 6724
P214
P244
P31
P496
0000-0002-3249-0468
P7859
lccn-n98802731