Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. - Wikidata - wikimedia - TriplyDB

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

http://www.wikidata.org/entity/Q40584948

about

Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies An overview of sphingolipid metabolism: from synthesis to breakdown A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death Evolving concepts in cancer therapy through targeting sphingolipid metabolism Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity Gene medicine for cancer treatment: commercially available medicine and accumulated clinical data in China The expression of sphingosine kinase-1 in head and neck carcinoma The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.A novel sphingosine kinase inhibitor induces autophagy in tumor cells.Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.Regulating survival and development in the retina: key roles for simple sphingolipids."Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde Defining a role for sphingosine kinase 1 in p53-dependent tumors.Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.Regulation and functions of sphingosine kinases in the brain Targeting SphK1 as a new strategy against cancer.p53 and regulation of bioactive sphingolipids.Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy p53 and Ceramide as Collaborators in the Stress Response Sphingolipids in the DNA damage response.Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells.DNA damage response and sphingolipid signaling in liver diseases.Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.p53-expressing conditionally replicative adenovirus CNHK500-p53 against hepatocellular carcinoma in vitro.Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin.Prediction of human protein-protein interaction by a mixed Bayesian model and its application to exploring underlying cancer-related pathway crosstalk.4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin.P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.Targeting S1P in Inflammatory bowel disease: new avenues for modulating intestinal leukocyte migration.TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.Role of sphingolipids in senescence: implication in aging and age-related diseases Insulin-like growth factor binding protein-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms

P2860

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P2860

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

http://www.wikidata.org/entity/Q40584948

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

@en

type

label

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

@en

prefLabel

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

@en

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P1433

Journal of Biological Chemistry

P1476

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53

@en

P2093

Ghassan S Dbaibo

http://www.w3.org/2001/XMLSchema#string

Jacek Bielawski

http://www.w3.org/2001/XMLSchema#string

Korey R Johnson

http://www.w3.org/2001/XMLSchema#string

Lina Kozhaya

http://www.w3.org/2001/XMLSchema#string

Tarek A Taha

http://www.w3.org/2001/XMLSchema#string

Walid Osta

http://www.w3.org/2001/XMLSchema#string

William E Gillanders

http://www.w3.org/2001/XMLSchema#string

P2860

Killing tumours by ceramide-induced apoptosis: a critique of available drugs

p53-dependent ceramide response to genotoxic stress

Actinomycin and DNA transcription

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

Sphingosine-1-phosphate: an enigmatic signalling lipid

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.

Apoptosis and cancer drug targeting.

Ceramide in the eukaryotic stress response.

Lysosomal destabilization in p53-induced apoptosis

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20546-20554

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10.1074/JBC.M401259200

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19

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279

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2004-02-26T00:00:00Z

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14988393

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