Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
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Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide AnaloguesThe Conformationally Constrained N -Methanocarba-dT Analogue Adopts an Unexpected C4′- exo Sugar Pucker in the Structure of a DNA HairpinA Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iotaBiochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cellsStructure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug designCharacterizing structural transitions using localized free energy landscape analysisImpact of sugar pucker on base pair and mispair stability.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Contrasting behavior of conformationally locked carbocyclic nucleosides of adenosine and cytidine as substrates for deaminases.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.Biophysical studies of DNA modified with conformationally constrained nucleotides: comparison of 2'-exo (north) and 3'-exo (south) 'locked' templatesEfficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virusSynthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives.Synthesis and conformational analysis of locked carbocyclic analogues of 1,3-diazepinone riboside, a high-affinity cytidine deaminase inhibitor.The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamerHighlights in antiviral drug research: antivirals at the horizon.Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.Antiviral Activity of 4'-thioIDU and Thymidine Analogs against OrthopoxvirusesDesign, synthesis and cellular metabolism study of 4'-selenonucleosides.Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.North- and south-bicyclo[3.1.0]hexene nucleosides: the effect of ring planarity on anti-HIV activity.Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima.Synthesis, structural characterization and biological evaluation of 4'-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides.Regioselective Synthesis of Pyrazolo[3,4-D]Pyrimidine Based Carbocyclic Nucleosides as Possible Antiviral Agent.Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.A conformational mimetic approach for the synthesis of carbocyclic nucleosides as anti-HCV leads.Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass.Reactions of Trimethylsilyl Fluorosulfonyldifluoroacetate with Purine and Pyrimidine Nucleosides.Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages.Synthesis of ethyl (1S,2R,3S,4S,5S)-2,3-O-(isopropylidene)-4-hydroxy-bicyclo[3.1.0]hexane-carboxylate from L-ribose: a versatile chiral synthon for preparation of adenosine and P2 receptor ligands.Prosit, an online service to calculate pseudorotational parameters of nucleosides and nucleotides.Rearranging the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve binding recognition by kinases.Influence of sugar ring conformation on the transportability of nucleosides by human nucleoside transporters.Polypharmacology of conformationally locked methanocarba nucleosides.
P2860
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P2860
Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Experimental and structural ev ...... on the basis of sugar pucker.
@en
type
label
Experimental and structural ev ...... on the basis of sugar pucker.
@en
prefLabel
Experimental and structural ev ...... on the basis of sugar pucker.
@en
P2093
P356
P1476
Experimental and structural ev ...... on the basis of sugar pucker.
@en
P2093
Joseph J Barchi
Karen M Green
Riad Agbaria
Tsipi Ben-Kasus
Victor E Marquez
P304
P356
10.1021/JA037929E
P407
P577
2004-01-01T00:00:00Z