Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.
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Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDOn the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesOmi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopyPreliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome.Discovery of small peptide antagonists of PED/PEA15-D4α interaction from simplified combinatorial libraries.Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin actionPED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanismClozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoterPeroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1Specific protein kinase C isoforms as transducers and modulators of insulin signalingTo activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils.The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism.Understanding type 2 diabetes: from genetics to epigenetics.Impact of commensal microbiota on murine gastrointestinal tract gene ontologies.Targetting PED/PEA-15 for diabetes treatment.PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport.NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites.Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake.Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
P2860
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P2860
Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Protein kinase C (PKC)-alpha a ...... the L6 skeletal muscle cells.
@en
type
label
Protein kinase C (PKC)-alpha a ...... the L6 skeletal muscle cells.
@en
prefLabel
Protein kinase C (PKC)-alpha a ...... the L6 skeletal muscle cells.
@en
P2093
P1433
P1476
Protein kinase C (PKC)-alpha a ...... the L6 skeletal muscle cells.
@en
P2093
F Beguinot
G Condorelli
G Vigliotta
M A Maitan
P Formisano
S Santopietro
P304
P356
10.2337/DIABETES.50.6.1244
P407
P577
2001-06-01T00:00:00Z