Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C.
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Structure of trans -Resveratrol in Complex with the Cardiac Regulatory Protein Troponin CCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeStructure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugsAllosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin CStrong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.Protein phosphorylation and signal transduction in cardiac thin filaments.The Ca2+/Mg2+ sites of troponin C modulate crossbridge-mediated thin filament activation in cardiac myofibrils.Correlating calcium binding, Förster resonance energy transfer, and conformational change in the biosensor TN-XXL.The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits magnesium binding to the C-domain of cardiac troponin CEnhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin CBiochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Molecular and functional consequences of mutations in the central helix of cardiac troponin C.Effect of hypertrophic cardiomyopathy-linked troponin C mutations on the response of reconstituted thin filaments to calcium upon troponin I phosphorylation.Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins.Evidence for troponin C (TNNC1) as a gene for autosomal recessive restrictive cardiomyopathy with fatal outcome in infancy.
P2860
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P2860
Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Hypertrophic cardiomyopathy-li ...... -domain of cardiac troponin C.
@en
type
label
Hypertrophic cardiomyopathy-li ...... -domain of cardiac troponin C.
@en
prefLabel
Hypertrophic cardiomyopathy-li ...... -domain of cardiac troponin C.
@en
P2860
P356
P1433
P1476
Hypertrophic cardiomyopathy-li ...... -domain of cardiac troponin C.
@en
P2093
Nicholas Swindle
Svetlana B Tikunova
P2860
P304
P356
10.1021/BI100400H
P407
P577
2010-06-01T00:00:00Z