Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists.
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Structural determinants of drug partitioning in n-hexadecane/water systemSolid phase synthesis of 2-aminobenzothiazolesMethods to assess drug permeability across the blood-brain barrier.High-throughput evaluation of relative cell permeability between peptoids and peptides.Medicinal chemical properties of successful central nervous system drugsFactors involved in the absence of sedative effects by the second-generation antihistamines.A method to predict blood-brain barrier permeability of drug-like compounds using molecular dynamics simulationsPhysicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model.Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferaseCC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinityPrediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates.A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction.The management of tuberculous meningitis.Use of biopartitioning micellar chromatography and RP-HPLC for the determination of blood-brain barrier penetration of α-adrenergic/imidazoline receptor ligands, and QSPR analysis.Modeling kinetics of subcellular disposition of chemicals.Lipophilicity and its relationship with passive drug permeation.Improving the prediction of drug disposition in the brain.Can we predict blood brain barrier permeability of ligands using computational approaches?Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research.Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain.The Histamine H3 Receptor: Structure, Pharmacology, and Function.Lipophilicity and biomimetic properties to support drug discovery.Fast investigations from biological matrices using CE--test of a blood-brain barrier model.Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system.Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.Predictivity approach for quantitative structure-property models. Application for blood-brain barrier permeation of diverse drug-like compounds.Copper- and palladium-catalyzed intramolecular C-S bond formation: a convenient synthesis of 2-aminobenzothiazoles.Determination of lipophilicity and hydrogen-bond donor acidity of bioactive sulphonyl-containing compounds by reversed-phase HPLC and centrifugal partition chromatography and their application to structure-activity relations.In Silico Prediction of Compounds Binding to Human Plasma Proteins by QSAR Models.Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D-Aromatic-Boron-Rich-Cluster into the 4-Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment.Computational prediction of CNS drug exposure based on a novel in vivo dataset.Molecular factors influencing drug transfer across the blood-brain barrier.Assessment of the classification abilities of the CNS multi-parametric optimization approach by the method of logistic regression.Rat protein binding and cerebral phospholipid affinity of the H3-receptor antagonist thioperamide.Physicochemical property profile for brain permeability: comparative study by different approaches.Strategies toward predicting peptide cellular permeability from computed molecular descriptors.ClogP(alk): a method for predicting alkane/water partition coefficient.
P2860
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P2860
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Development of a new physicoch ...... eceptor histamine antagonists.
@en
type
label
Development of a new physicoch ...... eceptor histamine antagonists.
@en
prefLabel
Development of a new physicoch ...... eceptor histamine antagonists.
@en
P2093
P356
P1476
Development of a new physicoch ...... eceptor histamine antagonists.
@en
P2093
C R Ganellin
D Saunders
R C Mitchell
R Griffiths
P304
P356
10.1021/JM00398A028
P407
P577
1988-03-01T00:00:00Z