miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors. - Wikidata - wikimedia - TriplyDB

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.

http://www.wikidata.org/entity/Q41899866

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A miR-19 regulon that controls NF-κB signaling β-Cell MicroRNAs: Small but Powerful Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes MicroRNAs as pharmacological targets in diabetes Role of regulatory micro RNAs in type 2 diabetes mellitus-related inflammation MicroRNAs: new insights into chronic childhood diseases Influence of miRNA in insulin signaling pathway and insulin resistance: micro-molecules with a major role in type-2 diabetes MicroRNA, nutrition, and cancer prevention Post-transcriptional regulation in metabolic diseases Regulatory Roles of MicroRNAs in Diabetes Epigenetics and Cellular Metabolism miR-24 regulates menin in the endocrine pancreas Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.The Biochemical Cascades of the Human Pancreatic β-Cells: The Role of MicroRNAs.MicroRNA-7a regulates pancreatic β cell function.MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor.miRNAs: novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes.Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.Cardiovascular importance of the microRNA-23/27/24 family.MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells.Analysis of differential miRNA expression in the duodenum of Escherichia coli F18-sensitive and -resistant weaned piglets Comparative microRNA expression profiles of cynomolgus monkeys, rat, and human reveal that mir-182 is involved in T2D pathogenic processes The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.MicroRNA expression in alpha and beta cells of human pancreatic islets.Minireview: microRNA function in pancreatic β cells.Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes.Deep sequencing of cardiac microRNA-mRNA interactomes in clinical and experimental cardiomyopathy.MiR-375 promotes redifferentiation of adult human β cells expanded in vitro Stem cell approaches for diabetes: towards beta cell replacement.Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65.DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs.Addressing Bias in Small RNA Library Preparation for Sequencing: A New Protocol Recovers MicroRNAs that Evade Capture by Current Methods.The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells.Organogenesis and functional genomics of the endocrine pancreas Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro.Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells.Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism.A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy.

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P2860

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.

http://www.wikidata.org/entity/Q41899866

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

miRNAs control insulin content ...... of transcriptional repressors.

@en

type

label

miRNAs control insulin content ...... of transcriptional repressors.

@en

prefLabel

miRNAs control insulin content ...... of transcriptional repressors.

@en

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P1433

The EMBO Journal

P1476

miRNAs control insulin content ...... of transcriptional repressors

@en

P2093

Amitai D Mandelbaum

http://www.w3.org/2001/XMLSchema#string

Eran Hornstein

http://www.w3.org/2001/XMLSchema#string

Kim A Lennox

http://www.w3.org/2001/XMLSchema#string

Natalia Rivkin

http://www.w3.org/2001/XMLSchema#string

Roni Oren

http://www.w3.org/2001/XMLSchema#string

Sharon Kredo-Russo

http://www.w3.org/2001/XMLSchema#string

Tal Melkman-Zehavi

http://www.w3.org/2001/XMLSchema#string

Tomer Nir

http://www.w3.org/2001/XMLSchema#string

Yuval Dor

http://www.w3.org/2001/XMLSchema#string

P2860

The nuclear RNase III Drosha initiates microRNA processing

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

MicroRNAs: target recognition and regulatory functions

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells

miR-375 maintains normal pancreatic alpha- and beta-cell mass

Combinatorial microRNA target predictions

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835-845

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scholarly article

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10.1038/EMBOJ.2010.361

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5

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30

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49802718

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21285947

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3049206

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