A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands.
about
A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3βUnderstanding ligand-receptor non-covalent binding kinetics using molecular modeling.Structural Analysis of Chemokine Receptor-Ligand Interactions.Synergistic combinations of the CCR5 inhibitor VCH-286 with other classes of HIV-1 inhibitors.Prolonged and tunable residence time using reversible covalent kinase inhibitors.Real time monitoring of membrane GPCR reconstitution by plasmon waveguide resonance: on the role of lipids.Scintillation proximity assay (SPA) as a new approach to determine a ligand's kinetic profile. A case in point for the adenosine A1 receptor.Quantitative analysis of receptor allosterism and its implication for drug discovery.On the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action.Flexible receptor docking for drug discovery.On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targetsHigh performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery.Drug-Target Kinetics in Drug Discovery.Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells.Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.Binding time--not just affinity--gains stature in drug design.Binding kinetics of cariprazine and aripiprazole at the dopamine D receptor
P2860
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P2860
A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
A study of the molecular mecha ...... l molecule allosteric ligands.
@en
A study of the molecular mecha ...... l molecule allosteric ligands.
@nl
type
label
A study of the molecular mecha ...... l molecule allosteric ligands.
@en
A study of the molecular mecha ...... l molecule allosteric ligands.
@nl
prefLabel
A study of the molecular mecha ...... l molecule allosteric ligands.
@en
A study of the molecular mecha ...... l molecule allosteric ligands.
@nl
P2093
P2860
P356
P1476
A study of the molecular mecha ...... l molecule allosteric ligands.
@en
P2093
David C Swinney
David M Rotstein
Georges Vauquelin
Jerome Deval
Kai-Ting Chuang
Marianna Dioszegi
Palani Ravendran
Paul Beavis
P2860
P304
P356
10.1111/BPH.12683
P407
P577
2014-07-01T00:00:00Z