Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
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Multiple Aspects of Gene Dysregulation in Huntington's DiseaseSirtuin 1 and sirtuin 3: physiological modulators of metabolismSIRT1 and SIRT2: emerging targets in neurodegenerationPGC-1α, mitochondrial dysfunction, and Huntington's diseaseMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Histone deacetylases and their role in motor neuron degenerationFrom sirtuin biology to human diseases: an updateHuntington's disease: underlying molecular mechanisms and emerging conceptsSirtuins in epigenetic regulationMaintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunctionEpigenetics and therapeutic targets mediating neuroprotectionNon-coding RNA in neural function, disease, and agingShaping the role of mitochondria in the pathogenesis of Huntington's diseaseRole of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisMitochondrial dysfunction in neurodegenerative diseasesAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemMetabolism in HD: still a relevant mechanism?Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signalingMitochondrial function in hypoxic ischemic injury and influence of agingSIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivoIntegration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicityHSF1 protects neurons through a novel trimerization- and HSP-independent mechanismSirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposureEthosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expressionThe stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's diseaseSirtuins: guardians of mammalian healthspan.NAD+ and sirtuins in aging and disease.Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacitySmall-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's diseaseIntrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expressionGenetic association of sirtuin genes and Parkinson's disease.Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.Sirtuin 1 activator SRT2104 protects Huntington's disease mice.
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P2860
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@en
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@nl
type
label
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@en
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@nl
prefLabel
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@en
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@nl
P2093
P2860
P50
P356
P1433
P1476
Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.
@en
P2093
Bronwen Martin
Dimitri Krainc
Hyunkyung Jeong
Jennifer Qian
Jiawei Wang
Jinrong Fu
Katherine Sommers
Kellie L K Tamashiro
P2860
P2888
P304
P356
10.1038/NM.2558
P407
P50
P577
2011-12-18T00:00:00Z