Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. - Wikidata - wikimedia - TriplyDB

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.

http://www.wikidata.org/entity/Q42097305

about

Multiple Aspects of Gene Dysregulation in Huntington's Disease Sirtuin 1 and sirtuin 3: physiological modulators of metabolism SIRT1 and SIRT2: emerging targets in neurodegeneration PGC-1α, mitochondrial dysfunction, and Huntington's disease Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Histone deacetylases and their role in motor neuron degeneration From sirtuin biology to human diseases: an update Huntington's disease: underlying molecular mechanisms and emerging concepts Sirtuins in epigenetic regulation Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction Epigenetics and therapeutic targets mediating neuroprotection Non-coding RNA in neural function, disease, and aging Shaping the role of mitochondria in the pathogenesis of Huntington's disease Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis Mitochondrial dysfunction in neurodegenerative diseases Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system Metabolism in HD: still a relevant mechanism?Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling Mitochondrial function in hypoxic ischemic injury and influence of aging SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease Sirtuins: guardians of mammalian healthspan.NAD+ and sirtuins in aging and disease.Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression Genetic association of sirtuin genes and Parkinson's disease.Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.Sirtuin 1 activator SRT2104 protects Huntington's disease mice.

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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.

http://www.wikidata.org/entity/Q42097305

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

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Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

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type

label

Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

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Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

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prefLabel

Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

@en

Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

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Nature Medicine

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Neuroprotective role of Sirt1 ...... ion of multiple Sirt1 targets.

@en

P2093

Bronwen Martin

http://www.w3.org/2001/XMLSchema#string

Dimitri Krainc

http://www.w3.org/2001/XMLSchema#string

Hyunkyung Jeong

http://www.w3.org/2001/XMLSchema#string

Jennifer Qian

http://www.w3.org/2001/XMLSchema#string

Jiawei Wang

http://www.w3.org/2001/XMLSchema#string

Jinrong Fu

http://www.w3.org/2001/XMLSchema#string

Katherine Sommers

http://www.w3.org/2001/XMLSchema#string

Kellie L K Tamashiro

http://www.w3.org/2001/XMLSchema#string

Lan Xiang

http://www.w3.org/2001/XMLSchema#string

Lin Du

http://www.w3.org/2001/XMLSchema#string

P2860

DARPP-32: regulator of the efficacy of dopaminergic neurotransmission

Negative control of p53 by Sir2alpha promotes cell survival under stress

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

Normal huntingtin function: an alternative approach to Huntington's disease

Modulation of SIRT1 expression in different neurodegenerative models and human pathologies

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

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153-158

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scholarly article

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10.1038/NM.2558

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P433

1

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P478

18

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Jiangyang Zhang

David M. Holtzman

Ruth Luthi-Carter

Tamara Seredenina

Christopher A Ross

P577

2011-12-18T00:00:00Z

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51897892

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P698

22179319

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Huntington disease

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4551453

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