about
Evolution of the relaxin-like peptide familyRelaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanismsRelaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathwaysIn a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilySilencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide functionThe NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activationStructure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 AgonistSolution structure, aggregation behavior, and flexibility of human relaxin-2H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2The human LGR7 low-density lipoprotein class A module requires calcium for structureReceptors for relaxin family peptidesSignal switching after stimulation of LGR7 receptors by human relaxin 2Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometrySplice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexityRelaxin receptors--new drug targets for multiple disease statesINSL5 is a high affinity specific agonist for GPCR142 (GPR100)Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptidesHuman relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide familyRelaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2Paracrine regulation of mammalian oocyte maturation and male germ cell survivalCharacterization of the rat INSL3 receptorDetection, localization, and action of the INSL3 receptor, LGR8, in rat kidneyINSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descentThe relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization.Chemical synthesis and biological activity of rat INSL3.The chemistry and biology of human relaxin-3.Purification and characterization of relaxin from the tammar wallaby (Macropus eugenii): bioactivity and expression in the corpus luteum.The molecular basis of oxytocin and oxytocin receptor gene expression in reproductive tissues.Characterisation of a cell-free synthesised G-protein coupled receptorML290 is a biased allosteric agonist at the relaxin receptor RXFP1.Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxinLuteal peptides and their genes as important markers of ovarian differentiation.INSL3/RXFP2 signaling in testicular descent.Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.Examination of relaxin and its receptors expression in pig gametes and embryos.Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Ross Bathgate
@ast
Ross Bathgate
@en
Ross Bathgate
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Ross Bathgate
@nl
Ross Bathgate
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type
label
Ross Bathgate
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Ross Bathgate
@en
Ross Bathgate
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Ross Bathgate
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Ross Bathgate
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altLabel
Ross A D Bathgate
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Ross Bathgate
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Ross Bathgate
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Ross Bathgate
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Ross Bathgate
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Ross Bathgate
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P1053
F-3525-2014
P106
P1153
16945482300
P21
P2798
P31
P3829
P496
0000-0001-6301-861X