Temporal separation of insulin-stimulated GLUT4/IRAP vesicle plasma membrane docking and fusion in 3T3L1 adipocytes.
about
The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes.A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cellsTUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recyclingInsulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes.Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy.Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle.Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependent.Insulin recruits GLUT4 from specialized VAMP2-carrying vesicles as well as from the dynamic endosomal/trans-Golgi network in rat adipocytesDiscrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutantCooling reduces cAMP-stimulated exocytosis and adiponectin secretion at a Ca2+-dependent step in 3T3-L1 adipocytesGLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomesSeparation of insulin signaling into distinct GLUT4 translocation and activation steps.Initial entry of IRAP into the insulin-responsive storage compartment occurs prior to basal or insulin-stimulated plasma membrane recycling.A specific dileucine motif is required for the GGA-dependent entry of newly synthesized insulin-responsive aminopeptidase into the insulin-responsive compartment.Differentiated 3T3L1 adipocytes are composed of heterogenous cell populations with distinct receptor tyrosine kinase signaling properties.Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane.
P2860
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P2860
Temporal separation of insulin-stimulated GLUT4/IRAP vesicle plasma membrane docking and fusion in 3T3L1 adipocytes.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@en
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@nl
type
label
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@en
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@nl
prefLabel
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@en
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@nl
P2093
P2860
P356
P1476
Temporal separation of insulin ...... nd fusion in 3T3L1 adipocytes.
@en
P2093
Boeglin DJ
Elmendorf JS
P2860
P304
37357-37361
P356
10.1074/JBC.274.52.37357
P407
P577
1999-12-01T00:00:00Z