SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.
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Current understanding of TRPM7 pharmacology and drug development for strokeGenetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophymiR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathwaysInvolvement of Na+/Ca2+ exchanger in migration and contraction of rat cultured tendon fibroblastsKnockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressurePolymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study.Stimulation of Na(+)/H(+) exchanger isoform 1 promotes microglial migrationCa2+ signalling in urethral interstitial cells of Cajal.Electroacupuncture reduces apoptotic index and inhibits p38 mitogen-activated protein kinase signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury.KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment.Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia.Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in ratsCombined actions of Na/K-ATPase, NCX1 and glutamate dependent NMDA receptors in ischemic rat brain penumbra.How Does the Ca(2+)-paradox Injury Induce Contracture in the Heart?-A Combined Study of the Intracellular Ca(2+) Dynamics and Cell Structures in Perfused Rat Hearts.Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure.Targeting cardiomyocyte Ca2+ homeostasis in heart failure.Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 productionRegional increase in extracellular potassium can be arrhythmogenic due to nonuniform muscle contraction in rat ventricular muscle.Preservation of mitochondrial function may contribute to cardioprotective effects of Na+/Ca2+ exchanger inhibitors in ischaemic/reperfused rat hearts.Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control.Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect stormAstrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.Direct Loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein.Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced T1 changes in isolated perfused rat hearts.Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats.Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heartmiR-185 inhibits endoplasmic reticulum stress-induced apoptosis by targeting Na+/H+ exchanger-1 in the heart.Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts.The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension.The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channelsThe effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra.TRPM7 in cerebral ischemia and potential target for drug development in stroke.Ionic transporter activity in astrocytes, microglia, and oligodendrocytes during brain ischemiaNew antiarrhythmic targets to control intracellular calcium handling.Glial Na(+) -dependent ion transporters in pathophysiological conditions.
P2860
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P2860
SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
SEA0400, a novel and selective ...... vivo cerebral ischemic models.
@en
SEA0400, a novel and selective ...... vivo cerebral ischemic models.
@nl
type
label
SEA0400, a novel and selective ...... vivo cerebral ischemic models.
@en
SEA0400, a novel and selective ...... vivo cerebral ischemic models.
@nl
prefLabel
SEA0400, a novel and selective ...... vivo cerebral ischemic models.
@en
SEA0400, a novel and selective ...... vivo cerebral ischemic models.
@nl
P2093
P1476
SEA0400, a novel and selective ...... vivo cerebral ischemic models
@en
P2093
Hamano-Takahashi A
Kawasaki Y
P304
P407
P577
2001-07-01T00:00:00Z