Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
about
Molecular and clinical implementations of ovarian cancer mouse avatar modelsHuman antibody production in transgenic animalsHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Antibody humanization by structure-based computational protein design.Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals.HIV-1 Env-specific memory and germinal center B cells in C57BL/6 miceCharacterizing immune repertoires by high throughput sequencing: strategies and applications.Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity.CRISPR-Cas9-mediated genome editing and guide RNA design.Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody.Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells.Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos.Efficient Qualitative and Quantitative Determination of Antigen-induced Immune Responses.In situ production of therapeutic monoclonal antibodies.HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies.Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform.Germline-targeting immunogens.Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design.Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic miceBroadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.From engineering to editing the rat genome.The contribution of homology arms to nuclease-assisted genome engineering.Computationally driven antibody engineering enables simultaneous humanization and thermostabilization.Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn.Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.Passive immunotherapy of viral infections: 'super-antibodies' enter the fray.Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering.Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows.Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy.Interrogation of the Atherosclerosis-Associated SORT1 (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies.Genome Writing: Current Progress and Related Applications.New models of human immunity.Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.Advanced model systems and tools for basic and translational human immunologyNovel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells
P2860
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P2860
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Complete humanization of the m ...... herapeutic antibody discovery.
@en
Complete humanization of the m ...... herapeutic antibody discovery.
@nl
type
label
Complete humanization of the m ...... herapeutic antibody discovery.
@en
Complete humanization of the m ...... herapeutic antibody discovery.
@nl
prefLabel
Complete humanization of the m ...... herapeutic antibody discovery.
@en
Complete humanization of the m ...... herapeutic antibody discovery.
@nl
P2093
P2860
P50
P356
P1433
P1476
Complete humanization of the m ...... therapeutic antibody discovery
@en
P2093
Adam Carpenter
Alastair Beasley
Alison Davis
Alla Fane-Dremucheva
Anais Legent
Anais Manin
Andrew Wood
Bettina Franz
Dominik Spensberger
E-Chiang Lee
P2860
P2888
P304
P356
10.1038/NBT.2825
P577
2014-03-16T00:00:00Z