Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time.

Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time.

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http://www.wikidata.org/entity/Q43783930
Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cellsOn the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action.On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targetsCell membranes… and how long drugs may exert beneficial pharmacological activity in vivoTargeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High-Affinity Bivalent Ligand.Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness.'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models.Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor.Selective, rapid and optically switchable regulation of protein function in live mammalian cells.Avidity and positive allosteric modulation/cooperativity act hand in hand to increase the residence time of bivalent receptor ligands.Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity.Link between a high for drug binding and a fast clinical action: to be or not to be?
P2860

Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time.

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http://www.wikidata.org/entity/Q43783930
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2013 nî lūn-bûn
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Simplified models for heterobi ...... t their target residence time.
@en
Simplified models for heterobi ...... t their target residence time.
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type
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Simplified models for heterobi ...... t their target residence time.
@en
Simplified models for heterobi ...... t their target residence time.
@nl
prefLabel
Simplified models for heterobi ...... t their target residence time.
@en
Simplified models for heterobi ...... t their target residence time.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
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P577
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Simplified models for heterobi ...... t their target residence time.
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P698
P921