Thermodynamically stable aggregation-resistant antibody domains through directed evolution.
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An update on antibody-based immunotherapies for Clostridium difficile infectionStability engineering of the human antibody repertoireClostridium difficile infection: molecular pathogenesis and novel therapeuticsEngineered single-domain antibodies with high protease resistance and thermal stabilityModulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutationsFully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid AntibodiesSequence determinants of protein aggregation in human VH domains.Bicistronic DNA display for in vitro selection of Fab fragmentsTherapeutic protein aggregation: mechanisms, design, and control.Detection of biomarkers using recombinant antibodies coupled to nanostructured platformsDisulfide linkage engineering for improving biophysical properties of human VH domains.Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display.Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display.Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activityProteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies.A novel heavy domain antibody library with functionally optimized complementarity determining regions.Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives.Stress selections on domain antibodies: 'what doesn't kill you makes you stronger'.Computational Design of the β-Sheet Surface of a Red Fluorescent Protein Allows Control of Protein OligomerizationCo-evolution of affinity and stability of grafted amyloid-motif domain antibodies.Engineered Autonomous Human Variable DomainsAntibody light chain variable domains and their biophysically improved versions for human immunotherapy.Candidate antibody-based therapeutics against HIV-1.Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions.Single-domain antibodies for biomedical applications.High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies.The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies.Optimizing protein stability in vivoImproving kinetic or thermodynamic stability of an azoreductase by directed evolution.Ultra scale-down characterization of the impact of conditioning methods for harvested cell broths on clarification by continuous centrifugation-Recovery of domain antibodies from rec E. coli.Structure-based engineering of a monoclonal antibody for improved solubility.Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions.Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.Quantification of M13 and T7 bacteriophages by TaqMan and SYBR green qPCR.Rational library design by functional CDR resampling.Enhanced stabilization of a stable single domain antibody for SEB toxin by random mutagenesis and stringent selection.Expression of high-affinity human antibody fragments in bacteria.FoldX as Protein Engineering Tool: Better Than Random Based Approaches?
P2860
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P2860
Thermodynamically stable aggregation-resistant antibody domains through directed evolution.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Thermodynamically stable aggre ...... ns through directed evolution.
@en
Thermodynamically stable aggre ...... ns through directed evolution.
@nl
type
label
Thermodynamically stable aggre ...... ns through directed evolution.
@en
Thermodynamically stable aggre ...... ns through directed evolution.
@nl
prefLabel
Thermodynamically stable aggre ...... ns through directed evolution.
@en
Thermodynamically stable aggre ...... ns through directed evolution.
@nl
P2093
P1476
Thermodynamically stable aggre ...... ns through directed evolution.
@en
P2093
Greg Winter
Kristoffer Famm
Lars Hansen
P304
P356
10.1016/J.JMB.2007.10.075
P407
P577
2007-11-04T00:00:00Z