Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. - Wikidata - wikimedia - TriplyDB

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

http://www.wikidata.org/entity/Q45078045

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Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1 Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion Lipotoxicity disrupts incretin-regulated human β cell connectivity An islet in distress: β cell failure in type 2 diabetes.Lipotoxicity in the heart.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes.Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.Glucose sensing in the pancreatic beta cell: a computational systems analysis.Mitochondrial uncoupling and lifespan.Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus.Glucolipotoxicity in Pancreatic β-Cells.Expression of PPARalpha modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice.Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells.Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells.Uncoupling protein 2 regulates glucagon-like peptide-1 secretion in L-cells.Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?Orphan nuclear receptors: therapeutic opportunities in skeletal muscle.Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect.UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.Uncoupling proteins: role in insulin resistance and insulin insufficiency Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan.Beta-cell failure as a complication of diabetes.Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2.Mitochondrial protein phosphorylation: instigator or target of lipotoxicity?Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions.Intracellular and extracellular adenosine triphosphate in regulation of insulin secretion from pancreatic β cells (β).

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P2860

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

http://www.wikidata.org/entity/Q45078045

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Free fatty acid-induced beta-c ...... coupling protein 2 expression.

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Free fatty acid-induced beta-c ...... coupling protein 2 expression.

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type

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Free fatty acid-induced beta-c ...... coupling protein 2 expression.

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Free fatty acid-induced beta-c ...... coupling protein 2 expression.

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prefLabel

Free fatty acid-induced beta-c ...... coupling protein 2 expression.

@en

Free fatty acid-induced beta-c ...... coupling protein 2 expression.

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Journal of Biological Chemistry

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Free fatty acid-induced beta-c ...... coupling protein 2 expression.

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P2093

Bradford B Lowell

http://www.w3.org/2001/XMLSchema#string

Chen-Yu Zhang

http://www.w3.org/2001/XMLSchema#string

Jamie W Joseph

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Monique C Saleh

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Vasilij Koshkin

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P2860

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

Superoxide activates mitochondrial uncoupling proteins

Method for the isolation of intact islets of Langerhans from the rat pancreas

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

Lipotoxic diseases.

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51049-51056

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10.1074/JBC.M409189200

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49

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279

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Catherine B. Chan

Michael B. Wheeler

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2004-09-23T00:00:00Z

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8267381

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15448158

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