The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).
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The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptorCorepressors: custom tailoring and alterations while you wait.Nuclear receptor corepressorsThe hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressorERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminusLinking dioxins to diabetes: epidemiology and biologic plausibilityStructure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interactionThe cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signalingThyroid hormone signaling in vivo requires a balance between coactivators and corepressorsThe nuclear corepressor, NCoR, regulates thyroid hormone action in vivoHairless is a nuclear receptor corepressor essential for skin function.Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptorA natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin.Estrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain.E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode.The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo.Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell linesComplex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines.Nuclear receptor corepressor recruitment by unliganded thyroid hormone receptor in gene repression during Xenopus laevis developmentNuclear receptor corepressor complexes in cancer: mechanism, function and regulationAlternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and βEstrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha gene promoter.Combinatorial roles of nuclear receptors in inflammation and immunity.The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism.The in vivo role of nuclear receptor corepressors in thyroid hormone action.Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing.Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties.Multiple mutations contribute to repression by the v-Erb A oncoprotein.Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity.Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptorsProgesterone receptor B recruits a repressor complex to a half-PRE site of the estrogen receptor alpha gene promoter.Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A.Alternative splicing generates multiple SMRT transcripts encoding conserved repressor domains linked to variable transcription factor interaction domains.Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosisA nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.Nuclear hormone receptor co-repressors: structure and function.Nuclear compartmentalization of N-CoR and its interactions with steroid receptors.
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P2860
The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
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2000年学术文章
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2000年學術文章
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2000年學術文章
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2000年學術文章
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name
The nuclear receptor corepress ...... tor interaction domains (IDs).
@en
The nuclear receptor corepressor
@nl
type
label
The nuclear receptor corepress ...... tor interaction domains (IDs).
@en
The nuclear receptor corepressor
@nl
prefLabel
The nuclear receptor corepress ...... tor interaction domains (IDs).
@en
The nuclear receptor corepressor
@nl
P2093
P356
P1476
The nuclear receptor corepress ...... ptor interaction domains (IDs)
@en
P2093
Anderson CM
Kushner PJ
Marimuthu A
Valentine C
P304
P356
10.1210/MEND.14.12.0566
P50
P577
2000-12-01T00:00:00Z