Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
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Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalitiesNaturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismPotential Roles of Adropin in Central Nervous System: Review of Current LiteratureInflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's DiseaseThe associations between Parkinson's disease and cancer: the plot thickensThe neurology of mTORErythropoietin: new directions for the nervous systemShedding new light on neurodegenerative diseases through the mammalian target of rapamycinSubcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disordersDriving neural regeneration through the mammalian target of rapamycinDistribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ AccumulationThe role of mTOR signaling in Alzheimer diseaseNO signaling and S-nitrosylation regulate PTEN inhibition in neurodegenerationRemoval of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behaviormTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease.Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signatureFunctional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia.Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.Why pleiotropic interventions are needed for Alzheimer's disease.Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human AstrocytesThe mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Honey bee PTEN--description, developmental knockdown, and tissue-specific expression of splice-variants correlated with alternative social phenotypes.Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease.Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity.Genetic determinants at the interface of cancer and neurodegenerative disease.Unveiling clusters of RNA transcript pairs associated with markers of Alzheimer's disease progression.Taking aim at Alzheimer's disease through the mammalian target of rapamycinAmyloid-β as a modulator of synaptic plasticityTumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.Fragile X mental retardation protein: from autism to neurodegenerative disease.Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers.Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.Ceramides as modulators of cellular and whole-body metabolism
P2860
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P2860
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@en
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@nl
type
label
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@en
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@nl
prefLabel
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@en
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@nl
P2093
P921
P1476
Activation of Akt/PKB, increas ...... Alzheimer's disease pathology.
@en
P2093
Aileen Moloney
Cora O'Neill
Janet A Johnston
Mary Kelliher
Peter Dockery
Rebecca J Griffin
Rivka Ravid
Rosemary O'Connor
P304
P356
10.1111/J.1471-4159.2004.02949.X
P407
P577
2005-04-01T00:00:00Z