Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
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RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to miceA myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinThe apolipoprotein E gene, attention, and brain function8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's diseaseIntegrative analysis of the melanoma transcriptomeEndophenotypes in normal brain morphology and Alzheimer's disease: a reviewStructure of a rat α1-macroglobulin receptor-binding domain dimerInflammation and Alzheimer's diseaseAlpha2 macroglobulin-like is essential for liver development in zebrafishPrion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegenerationExtensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's diseasePsychiatric genetics: back to the futureSoluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's diseaseA 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation.Amyloid oligomer conformation in a group of natively folded proteins.Genetic susceptibility to neurodevelopmental disorders.Genetic risk factors in Alzheimer's diseaseUse of genetic variation as biomarkers for Alzheimer's disease.An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disordersCellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo.Tau pathology generated by overexpression of tau.Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2.Lipoproteins in the central nervous system.Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrierInterleukin-1 and the immunogenetics of Alzheimer disease.LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis.Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.LRP in Alzheimer's disease: friend or foe?Family-based tests of association in the presence of linkage.Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity.The functions of the amyloid precursor protein gene.LDL receptor-related proteins in neurodevelopment.The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals
P2860
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P2860
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@en
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@nl
type
label
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@en
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@nl
prefLabel
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@en
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@nl
P2093
P356
P1433
P1476
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
@en
P2093
Bassett SS
Horvath SM
McInnis MG
P2888
P304
P356
10.1038/1243
P407
P577
1998-08-01T00:00:00Z