about
PcrA-mediated disruption of RecA nucleoprotein filaments--essential role of the ATPase activity of RecAForce and twist dependence of RepC nicking activity on torsionally-constrained DNA molecules.Fast, long-range, reversible conformational fluctuations in nucleosomes revealed by single-pair fluorescence resonance energy transfer.Single molecule force spectroscopy in biology using the atomic force microscope.Single-molecule studies of chromatin fibers: a personal report.Single-molecule analysis of chromatin.Homebuilt single-molecule scanning confocal fluorescence microscope studies of single DNA/protein interactions.Structure and dynamics of single DNA molecules manipulated by magnetic tweezers and or flow.The major chromatin protein histone H1 binds preferentially to cis-platinum-damaged DNADynamics of individual polymers using microfluidic based microcurvilinear flowChromatin fiber structure: morphology, molecular determinants, structural transitions.Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence.Assembly of single chromatin fibers depends on the tension in the DNA molecule: magnetic tweezers studyStretching and imaging single DNA molecules and chromatin.Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding.Binding of histones H1 and H5 and their globular domains to four-way junction DNA.Magnetic tweezers: a sensitive tool to study DNA and chromatin at the single-molecule level.cAMP signaling induces rapid loss of histone H3 phosphorylation in mammary adenocarcinoma-derived cell lines.Linker histone protects linker DNA on only one side of the core particle and in a sequence-dependent mannerSingle-molecule approaches reveal the idiosyncrasies of RNA polymerases.Visualization and analysis of chromatin by scanning force microscopy.Expedient placement of two fluorescent dyes for investigating dynamic DNA protein interactions in real time.Robust methods for purification of histones from cultured mammalian cells with the preservation of their native modifications.DNA helicase activity of PcrA is not required for the displacement of RecA protein from DNA or inhibition of RecA-mediated strand exchange.Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin.Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding.On the location of histones H1 and H5 in the chromatin fiber. Studies with immobilized trypsin and chymotrypsin.One-step fractionation method for isolating H1 histones from chromatin under nondenaturing conditionsRole of linker histones in extended chromatin fibre structureOn the location of linker DNA in the chromatin fiber. Studies with immobilized and soluble micrococcal nucleaseThe site of binding of linker histone to the nucleosome does not depend upon the amino termini of core histonesSingle-molecule biochemistry coming of ageA tightly regulated molecular motor based upon T7 RNA polymeraseSalt-urea, sulfopropyl-sepharose, and covalent chromatography methods for histone isolation and fractionation
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Sanford H Leuba
@nl
Sanford H Leuba
@sl
Sanford H. Leuba
@en
Sanford H. Leuba
@es
type
label
Sanford H Leuba
@nl
Sanford H Leuba
@sl
Sanford H. Leuba
@en
Sanford H. Leuba
@es
prefLabel
Sanford H Leuba
@nl
Sanford H Leuba
@sl
Sanford H. Leuba
@en
Sanford H. Leuba
@es
P106
P1153
55398667300
P31
P496
0000-0003-0278-7997