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The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA)Core Steps of Membrane-Bound Peptidoglycan Biosynthesis: Recent Advances, Insight and OpportunitiesThe crystal structure of HpcE, a bifunctional decarboxylase/isomerase with a multifunctional foldRefinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysisStructure and mechanism of HpcG, a hydratase in the homoprotocatechuate degradation pathway of Escherichia coliStructure and mechanism of HpcH: a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coliCrystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosisCrystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzaeSpecificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Enzyme Ternary ComplexCrystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound formsStructural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathwayFull-length structure of the major autolysin LytAEnzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerasesExpression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosisUse of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimeraseSurfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a.Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing.Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors.Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor.The pH dependence of polymerization and bundling by the essential bacterial cytoskeletal protein FtsZAllosteric activation in Bacillus stearothermophilus lactate dehydrogenase investigated by an X-ray crystallographic analysis of a mutant designed to prevent tetramerization of the enzyme.A model of membrane contraction predicting initiation and completion of bacterial cell division.Asymmetric triplex metallohelices with high and selective activity against cancer cells.Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activityExpression, purification and crystallization of the cell-division protein YgfE from Escherichia coli.Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faecium.Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins.Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa.Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.Bacterial cell wall assembly: still an attractive antibacterial target.Prospects for novel inhibitors of peptidoglycan transglycosylasesReconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.The mechanics of FtsZ fibers.Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coliKinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.Preliminary crystallographic analysis of 5-carboxymethyl-2-hydroxymuconate isomerase from Escherichia coli.CO₂directly modulates connexin 26 by formation of carbamate bridges between subunits.Expression, purification and crystallization of 2-oxo-hept-4-ene-1,7-dioate hydratase (HpcG) from Escherichia coli C.Structural characterisation of the insecticidal toxin XptA1, reveals a 1.15 MDa tetramer with a cage-like structure.
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P106
P21
P31
P496
0000-0003-0009-621X