about
Modeling ALS with motor neurons derived from human induced pluripotent stem cellsNeuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosisNeurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis.Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viabilityHypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic PrimingHypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytesEvidence for evolutionary divergence of activity-dependent gene expression in developing neuronsChorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction.Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells.Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease.Real-time quantitative monitoring of hiPSC-based model of macular degeneration on Electric Cell-substrate Impedance Sensing microelectrodes.Multidimensional apathy and executive dysfunction in amyotrophic lateral sclerosis.Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale.Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders.Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.Mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in amyotrophic lateral sclerosis.A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis.Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanismALS-specific cognitive and behavior changes associated with advancing disease stage in ALSDISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illnessCharacterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging studyReversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imagingMultiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiplRenewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies
P50
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P50
description
researcher ORCID ID = 0000-0001-6827-1593
@en
name
Siddharthan Chandran
@ast
Siddharthan Chandran
@en
Siddharthan Chandran
@es
Siddharthan Chandran
@nl
type
label
Siddharthan Chandran
@ast
Siddharthan Chandran
@en
Siddharthan Chandran
@es
Siddharthan Chandran
@nl
prefLabel
Siddharthan Chandran
@ast
Siddharthan Chandran
@en
Siddharthan Chandran
@es
Siddharthan Chandran
@nl
P31
P496
0000-0001-6827-1593