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Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytesReduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice.Molecular causes of aneuploidy in mammalian eggs.FACS-sorted putative oogonial stem cells from the ovary are neither DDX4-positive nor germ cells.DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint.Imaging Chromosome Separation in Mouse Oocytes by Responsive 3D Confocal Timelapse Microscopy.The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis.Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes.The control of meiotic maturation in mammalian oocytes.The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint.Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice.Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes.DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.Chromosome biorientation and APC activity remain uncoupled in oocytes with reduced volume.Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes.Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension.Chromosome structural anomalies due to aberrant spindle forces exerted at gene editing sites in meiosisSpindle tubulin and MTOC asymmetries may explain meiotic drive in oocytesMeiotic spindle assembly checkpoint and aneuploidy in males versus females.Phosphorylation of histone H3 in 1- and 2-cell embryosPerpetual sedimentation for the continuous delivery of particulate suspensionsAsymmetric confinement for defining outgrowth directionality
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Simon I R Lane
@en
Simon I R Lane
@nl
type
label
Simon I R Lane
@en
Simon I R Lane
@nl
prefLabel
Simon I R Lane
@en
Simon I R Lane
@nl
P31
P496
0000-0002-8155-0981