Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
about
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulationOptimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Regulation of Aicda expression and AID activityCytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1A role for the RNA pol II-associated PAF complex in AID-induced immune diversificationImmunoglobulin class-switch DNA recombination: induction, targeting and beyond.Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.Functional requirements of AID's higher order structures and their interaction with RNA-binding proteinsAccumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutationGANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instabilityA novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes.Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.TRIM28 prevents autoinflammatory T cell development in vivo.Transient AID expression for in situ mutagenesis with improved cellular fitness.
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P2860
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@ast
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en-gb
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@nl
type
label
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@ast
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en-gb
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@nl
prefLabel
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@ast
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en-gb
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@nl
P2093
P2860
P50
P921
P356
P1476
Histone chaperone Spt6 is requ ...... but not somatic hypermutation
@en
P2093
Hisaaki Taniguchi
Hitoshi Nagaoka
Katsuya Okawa
Kiyotsugu Yoshikawa
Maki Kobayashi
Reiko Shinkura
Shimpei Kawamoto
Shun-Ichiro Iemura
Yoko Kitawaki
P2860
P304
P356
10.1073/PNAS.1104423108
P407
P577
2011-05-10T00:00:00Z