Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania - sprookjes - yvandenbroek - TriplyDB

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

http://www.wikidata.org/entity/Q24595838

about

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods Trypanothione-dependent glyoxalase I in Trypanosoma cruzi Physiological consequences of drug resistance in Leishmania and their relevance for chemotherapy Comparative analysis of the omics technologies used to study antimonial, amphotericin B, and pentamidine resistance in leishmania Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p.Pentavalent antimonials: new perspectives for old drugs Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites.Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis Leishmania donovani develops resistance to drug combinations Role of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovani Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani Species-specific antimonial sensitivity in Leishmania is driven by post-transcriptional regulation of AQP1 Drug resistance in leishmaniasis Drug resistance in eukaryotic microorganisms.Antimony transport mechanisms in resistant leishmania parasites.Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani.The parasite-specific trypanothione metabolism of trypanosoma and leishmania.Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani.The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis P-glycoprotein A Gene Expression in Glucantime-Resistant and Sensitive Leishmania major (MRHO/IR/75/ER)Use of antimony in the treatment of leishmaniasis: current status and future directions.Antimony resistance in leishmania, focusing on experimental research.Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress.Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway Peroxiredoxins in parasites.Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony Earth Abides Arsenic Biotransformations Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.A new ABC half-transporter in Leishmania major is involved in resistance to antimony.Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress.Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli.Methylglyoxal metabolism in trypanosomes and leishmania.Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?Drug resistance in leishmaniasis: current drug-delivery systems and future perspectives.Metabolomic-based strategies for anti-parasite drug discovery.Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.

P2860

Q24649110-53F1B837-1494-416D-BA59-72524ECA5A49 Q24682276-7AAB9DEB-9266-4ABA-A7A0-B8097DAFEC7E Q24796588-09A33A1E-9DF8-4237-8FF2-DD28AF6CDAE2 Q27009505-38C7610D-6C4A-4B06-9826-A217F8E18489 Q27931456-4F745040-F140-4829-AD39-E6080B1D32B0 Q28253055-0C558150-F39F-4CEC-A6F0-D4E60C797634 Q28271918-7F2D6BD3-9406-4418-A553-E92B4D0EAEC0 Q28468760-FD921383-7FE3-470C-8B46-C36AFA42C091 Q28478242-DCACB2D0-BC2B-4A5F-9B14-63CA22B87669 Q28484463-C7DDFBB1-6BEB-49A6-8684-C5AA61B0817E Q28533525-E084752C-5C84-4F4A-A38B-DCA7C1DB881E Q28535444-9C5A6BAD-8912-4C81-A767-C68789B4208C Q28539382-999E0E37-41CC-467E-8EC6-37F87818B087 Q28543678-FFBEEF06-12A3-4384-93AB-0A6888F09FD1 Q29616242-A0A65995-CFFF-43DF-8796-D5BB28760E26 Q30248243-3822B6EB-49D9-4D4D-8C78-13D7534FCD7B Q33659312-4451899D-F220-4454-87D5-0C9E798A3936 Q33769084-1FFF4EA8-B3E9-497E-BE0E-52EDDF5A6A24 Q33966094-2C055135-8FAD-48F2-B66E-6A64C97C6CD4 Q34922108-AC300A1C-7D43-466F-861B-E7D7B25EA202 Q34940857-57CA4CCA-E269-4547-9383-B3FB81DA203A Q35047361-5AAB7C65-5868-4E16-9E66-0E50D000C9C2 Q35377767-1EBAB5B4-1BBC-4F8F-8BC4-FB35E2B63D07 Q35607561-1A0A718F-18BC-43F1-93A3-E1E2AE6202AE Q35860144-1E1782F0-1F02-4F20-8822-1143FBE03369 Q35903818-47ED633A-F3A0-4C3E-8C8A-77C38C68DE00 Q36026850-2C0CA2EE-6E0A-4586-8605-0B37160FB432 Q36047995-4DB2F511-CCC9-4851-B899-102F73E382FF Q36133198-E27A0E28-CA89-4589-890C-1D4101D43C72 Q36462027-29B52146-8C76-4754-9ADC-7F14447BB442 Q36482756-7880BF8B-2196-4BF5-B4DF-436B67A9EDAF Q36957213-A261421F-A64F-4F4F-8A6A-C9CFF4883E50 Q37036630-9E3028C7-9FB7-4AC7-8F3E-7548059E989B Q37698643-DC4E2FC5-92B2-4867-9CA8-896498474283 Q37734604-C0F60ADA-375A-4F46-8058-8982D9E5CAB7 Q37839329-F0F08EB8-4CD1-41F0-9654-EBAF9BD6799D Q38040818-35F5CA46-9DC5-4AF5-B629-1EBB0956A4D9 Q38154347-03B686E9-30EF-4C5E-81C1-F87B1C704F16 Q38256642-388171A5-401F-4F4E-929B-CE92D81FDEEB Q38327286-813FCFFF-2972-43EE-8DF7-323512C3863C

P2860

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

http://www.wikidata.org/entity/Q24595838

description

1996 nî lūn-bûn

@nan

1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

1996年の論文

@ja

1996年論文

@yue

1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu

name

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@ast

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@en

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@nl

type

label

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@ast

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@en

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@nl

prefLabel

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@ast

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@en

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@nl

P1433

Q24595838-F6217BBA-673A-45F1-91BD-53B8C83BCBB9

P1476

Q24595838-8A2342F3-A8DF-4E93-97A9-1AB0D89874AF

P2093

Q24595838-2BB94480-53A8-4FDF-998E-7B0048E1E4B3

Q24595838-5525FFF0-98B5-40EC-B34A-8E2770517FE4

Q24595838-617B8418-E30D-49A9-8D76-6BFD7E1A8E82

Q24595838-86F4E8DF-88DB-429C-A867-44AF3C928105

Q24595838-9B4742DB-B674-471B-B622-C106CCFC32C4

Q24595838-CA698926-B132-4849-8712-93ABC6247B49

P2860

Q24595838-01A3C493-26C5-4686-A94E-6AA08A34A015

Q24595838-207C8755-7D65-4B48-BC25-22748AE52062

Q24595838-496E81C7-BEFE-4CA4-9E9C-CABB74A8B054

Q24595838-5CB4B53E-E1D3-495B-BF2A-C7817A90B5A9

Q24595838-5E48B79F-F955-4B0F-AC8B-773C4D7D1FF6

Q24595838-6300CAA8-6C49-4A7D-9BCD-0522F72C7870

Q24595838-65587F54-6B82-4596-BFCC-CC58C8B3FEF6

Q24595838-68F6F3AC-7F45-4355-979E-6B36A61886B2

Q24595838-69A32D31-DDC3-4FA5-9FCB-A8780DF90454

Q24595838-6C9C40B3-D1AA-47D3-98F5-3A185CC39748

P304

Q24595838-0FFD8C5B-95D4-4837-ABC6-5ADFD9CFD0F6

P31

Q24595838-1BA4C38D-899F-40D5-98B9-0A25738FEC2A

P356

Q24595838-AB3C8B1C-24F6-44F4-8CC3-DAD75ACF0068

P407

Q24595838-A7CAEA1B-CB65-45C0-952E-A937BEED6DE8

P433

Q24595838-72B514D9-83C7-40AB-89B9-37092E4107C5

P478

Q24595838-0590DB80-410C-4D3E-B90B-94D2E51A7265

P50

Q24595838-2A73FF86-D33E-4A91-B174-289976629764

P577

Q24595838-1326362C-CAFC-453C-BA80-75C3000A3EAC

P5875

Q24595838-39EBE755-19B8-4010-A70D-DABE63BE72D0

P698

Q24595838-D087A0B5-41C8-4F44-BC2E-1B97751E96C7

P932

Q24595838-284597C5-F7B7-4003-88D6-673BC6484262

P356

PNAS.93.19.10383

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

@en

P2093

D Gage

http://www.w3.org/2001/XMLSchema#string

J Lightbody

http://www.w3.org/2001/XMLSchema#string

M Ouellette

http://www.w3.org/2001/XMLSchema#string

N Xu

http://www.w3.org/2001/XMLSchema#string

R Mukhopadhyay

http://www.w3.org/2001/XMLSchema#string

S Dey

http://www.w3.org/2001/XMLSchema#string

P2860

Protein measurement with the Folin phenol reagent

The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump

Biochemistry of multidrug resistance mediated by the multidrug transporter

Metabolism and functions of trypanothione in the Kinetoplastida.

Properties of the arsenate reductase of plasmid R773.

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258

An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae.

Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance.

Arsenical-resistant trypanosomes lack an unusual adenosine transporter.

P304

10383-10387

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.93.19.10383

http://www.w3.org/2001/XMLSchema#string

P407

P433

19

http://www.w3.org/2001/XMLSchema#string

P478

93

http://www.w3.org/2001/XMLSchema#string

P50

P577

1996-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

14388111

http://www.w3.org/2001/XMLSchema#string

P698

8816809

http://www.w3.org/2001/XMLSchema#string

P932

38393

http://www.w3.org/2001/XMLSchema#string