Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel - sprookjes - yvandenbroek - TriplyDB

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

http://www.wikidata.org/entity/Q27664399

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Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP Structure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channel Double electron-electron resonance reveals cAMP-induced conformational change in HCN channels.Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels Family of prokaryote cyclic nucleotide-modulated ion channels The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channels Flavonoid regulation of HCN2 channels.Structure and dynamics underlying elementary ligand binding events in human pacemaking channels A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.Exploring HCN channels as novel drug targets.Mechanism of electromechanical coupling in voltage-gated potassium channels.Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.Patch-clamp fluorometry: electrophysiology meets fluorescence.The where and how of PIP regulation of cone photoreceptor CNG channels.Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b.Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.Structure of a eukaryotic cyclic-nucleotide-gated channel.Normal-mode-analysis-guided investigation of crucial intersubunit contacts in the cAMP-dependent gating in HCN channels.Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance.State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).Elementary functional properties of single HCN2 channels.CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel.Structural insights into the mechanisms of CNBD channel function.The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns.Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides.Activation gating in HCN2 channels.A novel dimerization interface of cyclic nucleotide binding domain, which is disrupted in presence of cAMP: implications for CNG channels gating.Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

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Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

http://www.wikidata.org/entity/Q27664399

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@ast

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@en

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

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type

label

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@ast

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@en

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@nl

prefLabel

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@ast

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@en

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

@nl

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JBC.M110.152033

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Journal of Biological Chemistry

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Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

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Lei Zhou

http://www.w3.org/2001/XMLSchema#string

Qinglian Liu

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Xinping Xu

http://www.w3.org/2001/XMLSchema#string

Zhanna V Vysotskaya

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P2860

Two pacemaker channels from human heart with profoundly different activation kinetics

Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel

Pacemaker channel dysfunction in a patient with sinus node disease

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

Processing of X-ray diffraction data collected in oscillation mode

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels

C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels

Mapping the structure and conformational movements of proteins with transition metal ion FRET

Coot: model-building tools for molecular graphics

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285

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2010-11-19T00:00:00Z

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20829353

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HCN channel complex

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2978636

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