Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism
about
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesUbiquitin modificationsRegulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin LigasesRBR E3 ubiquitin ligases: new structures, new insights, new questionsParkin structure and functionStructure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 LigaseStructural basis for ligase-specific conjugation of linear ubiquitin chains by HOIPMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Molecular basis for specificity of the Met1-linked polyubiquitin signalTwo Distinct Types of E3 Ligases Work in Unison to Regulate Substrate UbiquitylationPerilous journey: a tour of the ubiquitin-proteasome systemStructural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.Structural and functional insights to ubiquitin-like protein conjugation.A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differentlyThe ubiquitination machinery of the ubiquitin system.Versatile roles of k63-linked ubiquitin chains in trafficking.USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkinItch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane DomainUsing protein motion to read, write, and erase ubiquitin signals.Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements.Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase.Genome-wide identification and characterization of RBR ubiquitin ligase genes in soybean.Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.HHARI is one HECT of a RING.RBR E3-ligases at workLysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases.Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.Specificity and disease in the ubiquitin systemParkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Ubiquitin and Parkinson's disease through the looking glass of genetics.Linear ubiquitin chains: enzymes, mechanisms and biologyDetermination of the pKa of the N-terminal amino group of ubiquitin by NMR.Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases.Mechanism of phospho-ubiquitin-induced PARKIN activation.Dual Function of Phosphoubiquitin in E3 Activation of Parkin.
P2860
Q24337489-56AD15AC-1048-4364-B5F2-B3D99A136E97Q26751380-D8EAD795-B951-41C9-8ACD-1AC677F5A52CQ26799441-C5BCB67B-DA37-4036-BF46-B825F782C819Q26828565-A6032CDB-2B8E-40B0-A0F1-1058B8522D67Q26995496-C162B770-6928-4091-92EE-4ABB90DF880DQ27680020-55BE7926-2A11-46D6-9483-4190184865D0Q27680404-1DA3DB55-A634-4561-B4BB-0896FBC9CD17Q28067393-304710A7-E906-45DD-A7F1-30152F040735Q28072740-D34FA18C-0FAF-4C8D-B901-A544E2923EB1Q28115944-FF94BA28-504C-4903-82E2-B94300AF431EQ28306492-4126675F-2DE8-463A-8148-49E54453BA54Q33773468-A5FFCE62-F398-4605-9DD0-5CF994ED6F2EQ33987001-818FDCCB-2191-48F9-9E39-D457D2548757Q34043219-5877B403-867F-4BBD-9C60-A513D93669ABQ34336982-1274C955-92BB-47BE-9AEB-3A910A1AE9B4Q34774715-39144A69-97B9-4DA3-B984-F7BEA006E4A9Q34815182-CE947DFC-8890-4382-9EB4-575DCECD1C01Q36093065-844524B3-037B-4BA3-8A19-56207552AA49Q36281694-5ECCB3E0-3A52-44F0-BD8E-7BD5F57297C0Q36283663-3487CE3E-D86D-4663-9E7D-F40B7653D77FQ36869071-F8C28DDA-9E53-4D45-9437-D3ADE6DEBF9CQ36884567-56D816EC-9FD5-46FE-B998-D29F6497F6CAQ37061493-C98DC257-F64F-4B02-9174-342E49E9CF6AQ37525611-6F841E48-D125-452D-83A1-AA084F70CB30Q37589985-03A4C69A-B862-498C-85C8-16EB6EF600BDQ37679387-07129B34-90F0-4B70-A5E3-6D0443322BF2Q38182404-AD23484D-D5AA-450D-8C35-DEACF50AB04CQ38201971-8CBEAFBC-FA48-4CE0-B8EC-C5390B025E14Q38576138-CC465182-34A9-40BF-8FE3-9BA7BF072432Q38584748-AE866E3F-6AC7-4B87-82C7-A0E7FB858AF2Q38633228-FD6D78EA-6091-4BF7-8DA4-69A9EA9198F5Q38728113-741DF5F9-3AA4-43C4-BC11-F906235AF777Q38834612-0DA0275D-0179-486A-8C45-3727601E6043Q38916854-4F3A59FC-7559-436C-AF9D-0F997AECBDCFQ39241365-DB8D93DB-FA11-4D23-82AD-5565105B2376Q39265294-4498C07A-C6D1-470F-B21D-EFF4FC76E139Q41864550-17B1C764-05F7-4DD1-9108-79D393058CA1Q42321764-8046BDA2-C8D9-453A-8DF3-AC01EC553178Q42356433-85D63762-D23C-4B51-97EA-30ED9138A621Q42380097-D3BF896E-FD43-4D83-80C0-BA9A727BFDA8
P2860
Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@ast
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@en
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@nl
type
label
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@ast
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@en
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@nl
prefLabel
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@ast
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@en
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@nl
P2093
P2860
P921
P3181
P1433
P1476
Structure of HHARI, a RING-IBR ...... sights into Ligation Mechanism
@en
P2093
Amanda Nourse
Arno F Alpi
Brenda A Schulman
Darcie J Miller
David M Duda
Igor Kurinov
Jennifer L Olszewski
Jonathan P Schuermann
P2860
P304
P3181
P356
10.1016/J.STR.2013.04.019
P577
2013-06-04T00:00:00Z