Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx
about
Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.Maintenance of adult cardiac function requires the chromatin factor Asxl2Cardiac deletion of Smyd2 is dispensable for mouse heart developmentAdditional sex combs-like family genes are required for normal cardiovascular developmentMouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesisEndangered species hold clues to human evolutionAdditional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in miceASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.Loss of Asxl2 leads to myeloid malignancies in miceDe novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndromeFunctional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.Additional sex combs-like 2 is required for polycomb repressive complex 2 binding at select targetsDrosophila Cyclin G and epigenetic maintenance of gene expression during developmentASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis.Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.Functional and cancer genomics of ASXL family membersDe Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype.Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics.The Role of Additional Sex Combs-Like Proteins in Cancer.Histone H2A Monoubiquitination in Neurodevelopmental Disorders.Inducible somatic oocyte destruction in response to rapamycin requires wild-type regulation of follicle cell epithelial polarity.ASXL2 mutations are frequently found in pediatric AML patients with t(8;21)/ RUNX1-RUNX1T1 and associated with a better prognosis.Asxl2-/- Mice Exhibit De Novo Cardiomyocyte Production during Adulthood.
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P2860
Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx
description
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
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artículu científicu espublizáu en 2009
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im Januar 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2009/01/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/01/01)
@nl
наукова стаття, опублікована в січні 2009
@uk
name
Functional conservation of Asx ...... ax and polycomb group gene Asx
@ast
Functional conservation of Asx ...... ax and polycomb group gene Asx
@en
Functional conservation of Asx ...... ax and polycomb group gene Asx
@nl
type
label
Functional conservation of Asx ...... ax and polycomb group gene Asx
@ast
Functional conservation of Asx ...... ax and polycomb group gene Asx
@en
Functional conservation of Asx ...... ax and polycomb group gene Asx
@nl
prefLabel
Functional conservation of Asx ...... ax and polycomb group gene Asx
@ast
Functional conservation of Asx ...... ax and polycomb group gene Asx
@en
Functional conservation of Asx ...... ax and polycomb group gene Asx
@nl
P2093
P2860
P921
P1433
P1476
Functional conservation of Asx ...... ax and polycomb group gene Asx
@en
P2093
David L. Geenen
Heather A. Baskind
Mayur P. Patel
Q. Tian Wang
Quanhong Ma
P2860
P356
10.1371/JOURNAL.PONE.0004750
P407
P577
2009-01-01T00:00:00Z