Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesCoupling of human circadian and cell cycles by the timeless protein.ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Rapid activation of ATR by ionizing radiation requires ATM and Mre11Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structuresCell-cycle checkpoints and cancerThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlConserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageDNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.DNA stimulates Mec1-mediated phosphorylation of replication protein A.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responsesNBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse.The multi-replication protein A (RPA) system--a new perspective.Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosisTipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Replication protein A: directing traffic at the intersection of replication and repair.Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forksFanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksIn vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signalingDistinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.Seipin is a discrete homooligomerDNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stressBringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint.DNA damage checkpoints in mammals.ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damageDNA mismatch repair and the DNA damage response.The ATM-dependent DNA damage signaling pathway.ATR signalling: more than meeting at the fork.TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity.
P2860
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P2860
Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/02/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/01)
@nl
наукова стаття, опублікована в лютому 2004
@uk
مقالة علمية (نشرت في فبراير 2004)
@ar
name
Quaternary structure of ATR an ...... binding and kinase activities
@ast
Quaternary structure of ATR an ...... binding and kinase activities
@en
Quaternary structure of ATR an ...... binding and kinase activities
@nl
type
label
Quaternary structure of ATR an ...... binding and kinase activities
@ast
Quaternary structure of ATR an ...... binding and kinase activities
@en
Quaternary structure of ATR an ...... binding and kinase activities
@nl
prefLabel
Quaternary structure of ATR an ...... binding and kinase activities
@ast
Quaternary structure of ATR an ...... binding and kinase activities
@en
Quaternary structure of ATR an ...... binding and kinase activities
@nl
P2860
P1476
Quaternary structure of ATR an ...... binding and kinase activities
@en
P2093
Keziban Unsal-Kaçmaz
P2860
P304
P356
10.1128/MCB.24.3.1292-1300.2003
P407
P50
P577
2004-02-01T00:00:00Z