Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region.

Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region.

Item
http://www.wikidata.org/entity/Q30195240
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATRac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activitiesFunctional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction.Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.Targeted inhibition of phospholipase C γ2 adaptor function blocks osteoclastogenesis and protects from pathological osteolysis.Enhanced phospholipase C-gamma1 activity produced by association of independently expressed X and Y domain polypeptides.Signal protein-derived peptides as functional probes and regulators of intracellular signaling.Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2.A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation.Mitogenic signaling from the egf receptor is attenuated by a phospholipase C-gamma/protein kinase C feedback mechanism.Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.Limited proteolysis of phospholipase C-gamma 1 indicates stable association of X and Y domains with enhanced catalytic activityEssential immunoregulatory role for BCAP in B cell development and function.
P2860

Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region.

Item
http://www.wikidata.org/entity/Q30195240
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Inhibitory effect of src homol ...... spholipase C inhibitor region.
@ast
Inhibitory effect of src homol ...... spholipase C inhibitor region.
@en
type
label
Inhibitory effect of src homol ...... spholipase C inhibitor region.
@ast
Inhibitory effect of src homol ...... spholipase C inhibitor region.
@en
prefLabel
Inhibitory effect of src homol ...... spholipase C inhibitor region.
@ast
Inhibitory effect of src homol ...... spholipase C inhibitor region.
@en
P1433
P1476
P2093
P304
P31
P407
P433
P478
P577
P698
P921
P1433
P1476
Inhibitory effect of src homol ...... ospholipase C inhibitor region
@en
P2093
P304
P31
P407
P433
P478
P577
P698
P921