3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.
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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptaseStructural basis of HIV-1 resistance to AZT by excisionViral mutation ratesMechanisms of viral mutationInfluence of reverse transcriptase variants, drugs, and Vpr on human immunodeficiency virus type 1 mutant frequencies.Deciphering Evolutionary Mechanisms Between Mutualistic and Pathogenic SymbiosesMutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excisionHuman immunodeficiency virus mutagenesis during antiviral therapy: impact of drug-resistant reverse transcriptase and nucleoside and nonnucleoside reverse transcriptase inhibitors on human immunodeficiency virus type 1 mutation frequencies.Stochastic interplay between mutation and recombination during the acquisition of drug resistance mutations in human immunodeficiency virus type 1Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity.Retroviral vectors for analysis of viral mutagenesis and recombination.5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response.Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance.Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.Analysis of selection pressure and mutational pattern of HIV type 1 reverse transcriptase region among treated and nontreated patients.Mutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.In search of a treatment for HIV--current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs).Rapid Determination of HIV-1 Mutant Frequencies and Mutation Spectra Using an mCherry/EGFP Dual-Reporter Viral Vector.Combination of drugs and drug-resistant reverse transcriptase results in a multiplicative increase of human immunodeficiency virus type 1 mutant frequenciesResolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication.Pathways to extinction: beyond the error threshold.Interrelationship between HIV-1 fitness and mutation rate.Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection.Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein.
P2860
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P2860
3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@en
type
label
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@en
prefLabel
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@en
P2860
P1433
P1476
3'-Azido-3'-deoxythymidine (AZ ...... immunodeficiency virus type 1.
@en
P2093
L C Bernard
L M Mansky
P2860
P304
P356
10.1128/JVI.74.20.9532-9539.2000
P577
2000-10-01T00:00:00Z