A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationPreferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damageThe Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathwaysCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Rapid activation of ATR by ionizing radiation requires ATM and Mre11DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.Function of a conserved checkpoint recruitment domain in ATRIP proteins.ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forksFanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksDNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.Protein phosphatase 5 is required for ATR-mediated checkpoint activation.A cell-permeable, activity-based probe for protein and lipid kinases.Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling.ATRIP oligomerization is required for ATR-dependent checkpoint signalingEpstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle.Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.
P2860
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P2860
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@ast
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@en
type
label
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@ast
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@en
prefLabel
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@ast
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@en
P2093
P2860
P356
P1476
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
@en
P2093
Karlene A Cimprich
Muh-Ching Yee
Ryan D Bomgarden
P2860
P304
13346-13353
P356
10.1074/JBC.M311098200
P407
P577
2004-01-14T00:00:00Z