Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. - sprookjes - yvandenbroek - TriplyDB

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

http://www.wikidata.org/entity/Q33668452

about

Regulation of global and specific mRNA translation by the mTOR signaling pathway Signalling to eIF4E in cancer The expanding role of mTOR in cancer cell growth and proliferation Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment T-cell intracellular antigens in health and disease La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells New frontiers in translational control of the cancer genome Growing knowledge of the mTOR signaling network.The nuclear import of ribosomal proteins is regulated by mTOR Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs.Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs mTOR coordinates protein synthesis, mitochondrial activity and proliferation.mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.The DPYSL2 gene connects mTOR and schizophrenia.mTOR in health and in sickness.La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs Molecular mechanisms of mTOR regulation by stress Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.Translation is actively regulated during the differentiation of CD8+ effector T cells.LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress.mTOR-sensitive translation: Cleared fog reveals more trees.Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo.Signaling pathways involved in the regulation of mRNA translation.

P2860

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P2860

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

http://www.wikidata.org/entity/Q33668452

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner.

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner.

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner.

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner.

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner.

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner.

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Journal of molecular cell biology

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Oxygen sufficiency controls TO ...... in a 4E-BP-independent manner

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Adam Avraham

http://www.w3.org/2001/XMLSchema#string

Elad Cohen

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Judith Kasir

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Markus A Rüegg

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Nadine Cybulski

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Oded Meyuhas

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Rachel Miloslavski

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Rajini Mudhasani

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Stephen N Jones

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Valentina Gandin

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P2860

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

Regulation of TOR by small GTPases

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

P304

255-266

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scholarly article

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10.1093/JMCB/MJU008

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3

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6

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Ivan Topisirovic

Arjuna Rajakumar

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2014-03-13T00:00:00Z

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260810351

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24627160

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4034726

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