Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.
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Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translationNovel amidines and analogues as promising agents against intracellular parasites: a systematic reviewComparative analysis of the omics technologies used to study antimonial, amphotericin B, and pentamidine resistance in leishmaniaNew Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid ParasitesRole of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovaniAn Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma bruceiCharacterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania majorDrug resistance in leishmaniasisAn Aromatic Diamidine That Targets Kinetoplast DNA, Impairs the Cell Cycle in Trypanosoma cruzi, and Diminishes Trypomastigote Release from Infected Mammalian Host Cells.Symmetrical choline-derived dications display strong anti-kinetoplastid activity.Novel arylimidamides for treatment of visceral leishmaniasis.Correlation between glucose uptake and membrane potential in Leishmania parasites isolated from DCL patients with therapeutic failure: a proof of concept.Structures, targets and recent approaches in anti-leishmanial drug discovery and development.The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomesLeishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.Aromatic diamidines as antiparasitic agents.Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.Polyamine metabolism in Leishmania: from arginine to trypanothione.ABC transporters involved in drug resistance in human parasites.Drug resistance in leishmaniasis: current drug-delivery systems and future perspectives.Polymeric colloidal particulate systems: intelligent tools for intracellular targeting of antileishmanial cargos.Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.Host cells participate in the in vitro effects of novel diamidine analogues against tachyzoites of the intracellular apicomplexan parasites Neospora caninum and Toxoplasma gondiiRole of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.4-amino bis-pyridinium derivatives as novel antileishmanial agents.Chemotherapy of leishmaniasis: present challenges.Redox biology of Leishmania and macrophage targeted nanoparticles for therapy.Nanostructured delivery systems with improved leishmanicidal activity: a critical review.An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.Drug resistance in leishmaniasis.Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts.Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.Uptake of T-2307, a novel arylamidine, in Candida albicans.Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II.Arginine and Polyamines Fate in Leishmania Infection.New insights in staging and chemotherapy of African trypanosomiasis and possible contribution of medicinal plants.Transporters in Anti-Parasitic Drug Development and Resistance
P2860
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P2860
Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@ast
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@en
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@nl
type
label
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@ast
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@en
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@nl
prefLabel
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@ast
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@en
Resistance to pentamidine in L ...... e drug from the mitochondrion.
@nl
P2860
P1476
Resistance to pentamidine in L ...... he drug from the mitochondrion
@en
P2093
Graham H Coombs
Mireille Basselin
P2860
P304
P356
10.1128/AAC.46.12.3731-3738.2002
P407
P577
2002-12-01T00:00:00Z