Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.
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Genetics of myeloproliferative neoplasmsProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesMyeloid malignancies: mutations, models and managementNovel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemiaMutant Cbl proteins as oncogenic drivers in myeloproliferative disordersUse of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemiaClinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasmsActivating CBL mutations are associated with a distinct MDS/MPN phenotype.Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignanciesThe genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaCbl and human myeloid neoplasms: the Cbl oncogene comes of age.Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.Identification of heptapeptides interacting with IFN-α-sensitive CML cells.Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolismCurrent outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms.Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies.Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia.Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes.Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignanciesComplex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2.CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts.Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemiaMutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesisCytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.Novel somatic and germline mutations in intracranial germ cell tumours.Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemiaUsing an exon microarray to identify a global profile of gene expression and alternative splicing in K562 cells exposed to sodium valproate.UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis
P2860
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P2860
Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@ast
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@en
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@nl
type
label
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@ast
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@en
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@nl
prefLabel
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@ast
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@en
Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.
@nl
P2093
P2860
P356
P1476
Mutations of e3 ubiquitin liga ...... lesion in myeloid malignancies
@en
P2093
Andrew Dunbar
Christine O'Keefe
Hadrian Szpurka
Heather Cazzolli
Hideki Makishima
Hideki Muramatsu
Jaroslaw P Maciejewski
Jungwon Huh
Michael A McDevitt
P2860
P304
P356
10.1200/JCO.2009.23.7503
P407
P50
P577
2009-11-09T00:00:00Z