Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.
about
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteinsRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Advances in targeting cyclic nucleotide phosphodiesterasesCyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.The Popeye Domain Containing Genes and their Function in Striated MuscleThe role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatmentRecapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions.Heart failure-specific changes in protein kinase signalling.Cyclic nucleotide phosphodiesterases (PDEs): coincidence detectors acting to spatially and temporally integrate cyclic nucleotide and non-cyclic nucleotide signals.The cardioprotective role of small heat-shock protein 20.cAMP signaling in subcellular compartments.Phosphodiesterase-4 inhibition as a therapeutic strategy for metabolic disorders.The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus.Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy.Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation.PDE4-Mediated cAMP Signalling.The importance of drug discovery for treatment of cardiovascular diseases.
P2860
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P2860
Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.
description
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
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name
Targeting protein-protein inte ...... gy for cardiovascular disease.
@ast
Targeting protein-protein inte ...... gy for cardiovascular disease.
@en
Targeting protein-protein inte ...... gy for cardiovascular disease.
@nl
type
label
Targeting protein-protein inte ...... gy for cardiovascular disease.
@ast
Targeting protein-protein inte ...... gy for cardiovascular disease.
@en
Targeting protein-protein inte ...... gy for cardiovascular disease.
@nl
prefLabel
Targeting protein-protein inte ...... gy for cardiovascular disease.
@ast
Targeting protein-protein inte ...... gy for cardiovascular disease.
@en
Targeting protein-protein inte ...... gy for cardiovascular disease.
@nl
P2093
P2860
P356
P1476
Targeting protein-protein inte ...... gy for cardiovascular disease.
@en
P2093
Donald H Maurice
George S Baillie
Louisa C Y Lee
P2860
P304
P356
10.4155/FMC.12.216
P577
2013-03-01T00:00:00Z