Targeting of AID-mediated sequence diversification to immunoglobulin genes - sprookjes - yvandenbroek - TriplyDB

Targeting of AID-mediated sequence diversification to immunoglobulin genes

Targeting of AID-mediated sequence diversification to immunoglobulin genes

http://www.wikidata.org/entity/Q34777596

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Generation and repair of AID-initiated DNA lesions in B lymphocytes.Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component.AID-initiated DNA lesions are differentially processed in distinct B cell populations.Complex regulation and function of activation-induced cytidine deaminase.Identification of core DNA elements that target somatic hypermutation.Defining chromosomal translocation risks in cancer.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.The role of activation-induced deaminase in antibody diversification and genomic instability.Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.

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P2860

Targeting of AID-mediated sequence diversification to immunoglobulin genes

http://www.wikidata.org/entity/Q34777596

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@ast

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@en

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@nl

type

label

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@ast

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@en

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@nl

prefLabel

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@ast

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@en

Targeting of AID-mediated sequence diversification to immunoglobulin genes

@nl

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J.COI.2010.12.009

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Current Opinion in Immunology

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Targeting of AID-mediated sequence diversification to immunoglobulin genes

@en

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Sebastian D Fugmann

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.

Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.

Attracting AID to targets of somatic hypermutation.

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

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184-189

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scholarly article

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10.1016/J.COI.2010.12.009

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2

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23

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Naga Rama Kothapalli

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2011-02-02T00:00:00Z

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49811780

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21295456

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3073656

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