TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements - sprookjes - yvandenbroek - TriplyDB

TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements

TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements

http://www.wikidata.org/entity/Q35924992

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FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.Pathogenesis of FUS-associated ALS and FTD: insights from rodent models FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.RNA seeds higher-order assembly of FUS protein.FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.Nucleic acid-binding specificity of human FUS protein.Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration.Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes.Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.Functions of FUS/TLS from DNA repair to stress response: implications for ALS.PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.Altered mRNP granule dynamics in FTLD pathogenesis.ALS mutations in TLS/FUS disrupt target gene expression.Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats.TDP-43 and FUS en route from the nucleus to the cytoplasm.The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site.Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.RNA-mediated toxicity in neurodegenerative disease A multifunctional protein, EWS, is essential for early brown fat lineage determination.The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease.The role of FUS gene variants in neurodegenerative diseases.Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia.Position-specific binding of FUS to nascent RNA regulates mRNA length.Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding.Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.RGG boxes within the TET/FET family of RNA-binding proteins are functionally distinct.TLS/FUS: a protein in cancer and ALS.RNA-binding proteins in neurodegeneration: mechanisms in aggregate.

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TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements

http://www.wikidata.org/entity/Q35924992

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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PNAS.1203028109

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Proceedings of the National Academy of Sciences of the United States of America

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TLS/FUS (translocated in lipos ...... stranded DNA response elements

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Adelene Y Tan

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Harmen J Bussemaker

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James L Manley

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Todd R Riley

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Tristan Coady

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P2860

Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II

TLS inhibits RNA polymerase III transcription

Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA

Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation

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6030-6035

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scholarly article

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16

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109

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2012-03-29T00:00:00Z

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223989573

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22460799

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3341064

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