Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region
about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesIgH chain class switch recombination: mechanism and regulationActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.AID targeting is dependent on RNA polymerase II pausing.AID and Apobec3G haphazard deamination and mutational diversityMeiotic recombination hotspots of fission yeast are directed to loci that express non-coding RNA.AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.AID and somatic hypermutation.A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Mechanism and regulation of class switch recombinationOverlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genesComplexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids.Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination.Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations.AIDing antibody diversity by error-prone mismatch repair.The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombinationThree-dimensional architecture of the IgH locus facilitates class switch recombination.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Transcription induces strand-specific mutations at the 5' end of human genes.Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regionsTranscriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.AID hits the jackpot when missing the target.Switch region identity plays an important role in Ig class switch recombination.G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafterImmunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombinationDNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.AID: a riddle wrapped in a mystery inside an enigma.A transcriptional serenAID: the role of noncoding RNAs in class switch recombination.Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.The role of G-density in switch region repeats for immunoglobulin class switch recombination.The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites.Nascent Connections: R-Loops and Chromatin Patterning.Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots.
P2860
Q24337929-C9ABB520-3272-492F-91B5-1B3AF07E8F9BQ27001131-64780085-E0CC-424F-97FF-DEC926C360B3Q27337984-EFBECCF0-13AE-4DA7-B292-865415C34C54Q27692655-925CBA86-C724-4E65-AE08-575D57EB5D12Q30537745-7519BAE3-14AF-486C-8EE1-B095C4E421CDQ33358102-8BE45DCB-18A8-47C7-950F-FF3B3874474EQ33563951-8DDF7BF3-57D9-42EA-901A-2F0E93812F13Q33734070-DEBB4180-F71C-413E-97E6-CD206DBE765CQ33839428-4CE91729-ECB9-4713-9F32-C57F06529F19Q34118000-B5E055D5-0039-43D0-B3D2-836C32CDCD2FQ34133261-6565E206-C2E3-48AE-8CA7-306E8F4A8E3DQ34162337-5A7AAE97-6B5C-4115-A870-7B80759C7F7DQ34189624-6595587F-4E4A-4E6C-9E6D-05FA5A57AA5AQ34375128-D7E2D205-7DDF-41AC-BBCE-688E46E58037Q34764888-26D60847-160A-4F39-B5AE-3940D5E5CD92Q35105143-B08D034C-96A8-481A-BB50-CF9AA33409AFQ35587316-6D589DA6-8E0E-4D40-877A-2FC96601901CQ35609131-359EE89D-4488-4DF3-98CF-A059769DFC8EQ35706806-F40CD04A-1D34-41EC-9630-BA83E0C537EEQ35992414-0FECE8DF-FAA6-49FE-872C-8EC2BD6A2502Q36173942-1A715EF2-6111-4F9A-957B-72C453E55E02Q36191111-4804DCB5-3765-48B9-9A04-F2BB8B9960ECQ36235676-D5313E93-291F-4337-AD7F-95BD671F7B29Q36534234-BE738495-C94E-4DB1-8474-52A522BE66F0Q36804846-B620AB89-7800-4C85-BFDB-4955DF42A143Q36842394-26328640-BCF0-499F-ACF0-914E6DE32274Q37061670-8C2C1683-7968-49C4-B756-CDD8431D8167Q37164471-E14C2D02-DF8D-4D46-A495-FE60095B463DQ37164484-EAD467CC-F90B-409D-9F7F-1F953C196C72Q37192001-DE9AB7E3-4130-4138-9AD5-7EF482367409Q37273168-F31B9825-7B6B-46DA-B7CD-30309876FA5DQ37292763-56B22145-AE0E-47F2-A5EE-4B7962B81F0AQ37724828-F8749EBB-A8AA-4203-A931-5C99DC3985A3Q37815430-79BED6B4-6042-4AAE-8F85-7E919C9E7C76Q38680202-6E3025DC-2062-4A1D-9D12-9183879615DCQ38906972-77D3E683-25E1-4F41-93E3-E2A7312549FAQ38942027-8D101D51-61AD-4BB2-A0F0-87E67AC0AFA2Q38975929-EDEB6A32-49CC-4166-9E1A-7336A50A33AFQ38993930-E7846794-A224-46EC-A877-7BFA5505AABBQ41880933-12EE14FC-494A-421E-9D36-AF7922ADF2F4
P2860
Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Sequence dependence of chromos ...... -chain Smu class switch region
@ast
Sequence dependence of chromos ...... -chain Smu class switch region
@en
type
label
Sequence dependence of chromos ...... -chain Smu class switch region
@ast
Sequence dependence of chromos ...... -chain Smu class switch region
@en
prefLabel
Sequence dependence of chromos ...... -chain Smu class switch region
@ast
Sequence dependence of chromos ...... -chain Smu class switch region
@en
P2093
P2860
P356
P1476
Sequence dependence of chromos ...... -chain Smu class switch region
@en
P2093
Barbara B Balter
Chih-Lin Hsieh
Erik Selsing
Feng-Ting Huang
Michael R Lieber
Zeliha Oruc
P2860
P304
P356
10.1128/MCB.00702-07
P407
P577
2007-06-11T00:00:00Z