Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase
about
Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assaysA synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancersA Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic ReprogrammingTargeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease?Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male MiceInhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR InhibitorsActivation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral ReplicationA patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cellsTargeting DNA Repair in Cancer: Beyond PARP Inhibitors.Modeling amplified p53 responses under DNA-PK inhibition in DNA damage responseThe essential kinase ATR: ensuring faithful duplication of a challenging genome.The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.Modulation of the DNA damage response during the life cycle of human papillomaviruses.S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.The Role of the Transcriptional Response to DNA Replication Stress.Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage.Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization.HPV31 utilizes the ATR-Chk1 pathway to maintain elevated RRM2 levels and a replication-competent environment in differentiating Keratinocytes.Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin.Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity.Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes.53BP1 and BRCA1 control pathway choice for stalled replication restart.Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation.Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation.ATR/CHK1 inhibitors and cancer therapy.Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.53BP1 Mediates ATR-Chk1 Signaling And Protects Replication Forks Under Conditions Of Replication Stress.APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.The ATR inhibitor AZD6738 synergizes with gemcitabine in vitro and in vivo to induce pancreatic ductal adenocarcinoma regression.Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
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P2860
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Distinct but Concerted Roles o ...... lication Stress during S Phase
@ast
Distinct but Concerted Roles o ...... lication Stress during S Phase
@en
type
label
Distinct but Concerted Roles o ...... lication Stress during S Phase
@ast
Distinct but Concerted Roles o ...... lication Stress during S Phase
@en
prefLabel
Distinct but Concerted Roles o ...... lication Stress during S Phase
@ast
Distinct but Concerted Roles o ...... lication Stress during S Phase
@en
P2093
P2860
P1433
P1476
Distinct but Concerted Roles o ...... lication Stress during S Phase
@en
P2093
Cyril H Benes
Jessica L Boisvert
Rémi Buisson
P2860
P304
P356
10.1016/J.MOLCEL.2015.07.029
P577
2015-09-10T00:00:00Z