Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
about
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinismPDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITFIdentification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradationPNG1, a yeast gene encoding a highly conserved peptide:N-glycanaseDeregulated E2F transcriptional activity in autonomously growing melanoma cellsMLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanomaThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyMechanisms regulating skin pigmentation: the rise and fall of complexion colorationThe molecular basis of oculocutaneous albinism type 1 (OCA1): sorting failure and degradation of mutant tyrosinases results in a lack of pigmentationIntegrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implicationsInefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surfaceEndo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cellsThe cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functionsN-glycosylation enhances presentation of a MHC class I-restricted epitope from tyrosinaseThe class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosolInterferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells.Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease.Proper folding and endoplasmic reticulum to golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine.p38 regulates pigmentation via proteasomal degradation of tyrosinase.Calreticulin: one protein, one gene, many functions.Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma.Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traitsQuasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disordersQuality control of transmembrane domain assembly in the tetraspanin CD82A role for N-glycanase in the cytosolic turnover of glycoproteins.The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells.The cytoplasmic peptide:N-glycanase (Ngly1)-basic science encounters a human genetic disorder.Isolated amelanotic malignant melanoma of the heart.Genes and pathways downstream of telomerase in melanoma metastasisReglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation.Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding siteMicrophthalmia transcription factor. A sensitive and specific melanocyte marker for MelanomaDiagnosis.A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum.Mechanisms of protein delivery to melanosomes in pigment cells.Involvement of dynein and spectrin with early melanosome transport and melanosomal protein traffickingTyrosinase maturation through the mammalian secretory pathway: bringing color to life.Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.
P2860
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P2860
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@ast
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@en
type
label
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@ast
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@en
prefLabel
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@ast
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@en
P2093
P2860
P4510
P356
P1476
Aberrant retention of tyrosina ...... e of amelanotic melanoma cells
@en
P2093
D N Hebert
G Moellmann
M Michalak
V Setaluri
P2860
P304
P356
10.1073/PNAS.94.12.6210
P407
P577
1997-06-01T00:00:00Z