High mutation rate of a spleen necrosis virus-based retrovirus vector
about
The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein5-Azacytidine and RNA secondary structure increase the retrovirus mutation rateThe bovine leukemia virus encapsidation signal is discontinuous and extends into the 5' end of the gag geneLower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptaseSequence and functional differences between Schmidt-Ruppin D and Schmidt-Ruppin A strains of pp60v-srcBroad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutationsBroad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-RelNuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences.Development of multigene and regulated lentivirus vectors.Most retroviral recombinations occur during minus-strand DNA synthesis.In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy.Exon trapping: a genetic screen to identify candidate transcribed sequences in cloned mammalian genomic DNA.Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein.Murine retroviruses re-engineered for lineage tracing and expression of toxic genes in the developing chick embryo.Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo.A promoterless retroviral vector indicates that there are sequences in U3 required for 3' RNA processing.Central and peripheral retina arise through distinct developmental pathsMutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity.GAL4-I kappa B alpha and GAL4-I kappa B gamma activate transcription by different mechanisms.The C terminus of the NF-kappa B p50 precursor and an I kappa B isoform contain transcription activation domains.Key determinants of target DNA recognition by retroviral intasomes.Somatic transgenesis using retroviral vectors in the chicken embryo.High rate of mismatch extension during reverse transcription in a single round of retrovirus replicationThe relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha.Inducible human immunodeficiency virus type 1 packaging cell linesDevelopment of 2A peptide-based strategies in the design of multicistronic vectors.Reduction of type V collagen using a dominant-negative strategy alters the regulation of fibrillogenesis and results in the loss of corneal-specific fibril morphology.Lower mutation rate of bovine leukemia virus relative to that of spleen necrosis virus.High rates of frameshift mutations within homo-oligomeric runs during a single cycle of retroviral replication.Retrovirus recombination depends on the length of sequence identity and is not error proneReplication of the retroviral terminal repeat sequence during in vivo reverse transcription.Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59v-rel.Differential pp40I kappa B-beta inhibition of DNA binding by rel proteinsUnusually high frequency of reconstitution of long terminal repeats in U3-minus retrovirus vectors by DNA recombination or gene conversion.vRel is an inactive member of the Rel family of transcriptional activating proteins.Spleen necrosis virus, an avian immunosuppressive retrovirus, shares a receptor with the type D simian retrovirusesDirect determination of the point mutation rate of a murine retrovirus.Effect of gamma radiation on retroviral recombination.Oncogenic transformation by vrel requires an amino-terminal activation domain
P2860
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P2860
High mutation rate of a spleen necrosis virus-based retrovirus vector
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
High mutation rate of a spleen necrosis virus-based retrovirus vector
@en
type
label
High mutation rate of a spleen necrosis virus-based retrovirus vector
@en
prefLabel
High mutation rate of a spleen necrosis virus-based retrovirus vector
@en
P2860
P356
P1476
High mutation rate of a spleen necrosis virus-based retrovirus vector
@en
P2093
J P Dougherty
P2860
P304
P356
10.1128/MCB.6.12.4387
P407
P577
1986-12-01T00:00:00Z