Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. - sprookjes - yvandenbroek - TriplyDB

Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.

Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.

http://www.wikidata.org/entity/Q37040974

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Kynurenines in CNS disease: regulation by inflammatory cytokines Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders.Drosophila eye color mutants as therapeutic tools for Huntington disease.

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Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.

http://www.wikidata.org/entity/Q37040974

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 March 2010

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Dysfunctional kynurenine pathw ...... model of Huntington's disease.

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Dysfunctional kynurenine pathw ...... model of Huntington's disease.

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Dysfunctional kynurenine pathw ...... model of Huntington's disease.

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Dysfunctional kynurenine pathw ...... model of Huntington's disease.

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Dysfunctional kynurenine pathw ...... model of Huntington's disease.

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Dysfunctional kynurenine pathw ...... model of Huntington's disease.

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J.1471-4159.2010.06675.X

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Journal of Neurochemistry

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Dysfunctional kynurenine pathw ...... model of Huntington's disease.

@en

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Erin K Stachowski

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Korrapati V Sathyasaikumar

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Laura Amori

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Paolo Guidetti

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Paul J Muchowski

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Robert Schwarcz

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P2860

Protein measurement with the Folin phenol reagent

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice.

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

Early kynurenergic impairment in Huntington's disease and in a transgenic animal model

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

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1416-1425

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scholarly article

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10.1111/J.1471-4159.2010.06675.X

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2010-03-17T00:00:00Z

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42254449

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20236387

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Huntington disease

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3721540

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