Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.
about
Usage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytesUsing chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.Can 'humanized' mice improve drug development in the 21st century?Mice with chimeric livers are an improved model for human lipoprotein metabolismThe nude mouse as model for liver deficiency study and treatment and xenotransplantation.Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice.Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2.Lumiracoxib metabolism in male C57bl/6J mice: characterisation of novel in vivo metabolites.Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone.Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals.Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans.The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
P2860
Q27306083-F6DB5BF0-3F38-47FC-92F4-79A551F46BF0Q30010631-1EBE71FE-B5C4-448D-A3E7-9A97AD32CF3CQ31002556-4FC36D88-509E-4A0B-8D31-783F15BC5AAAQ34340443-9C823B1A-11D6-4BD9-8038-324D104BD671Q35040968-19D4E9FB-CD74-45D6-8A39-4DC48576A83FQ36411268-25DEC299-3B6F-4508-8AE3-E3C7018BCCA2Q38151571-C4E37FD5-3AFC-4829-90DD-FCF27616F248Q38169790-C594C975-F0B7-461F-8D99-F8067D669306Q38170468-43499E48-9C3C-4076-9750-492527FA408DQ40550521-D56CD6EB-950C-493B-BC2A-387D84B146F6Q44160577-64CF5435-66B6-4518-A331-61E362DA48F2Q44279130-CD996957-8E96-4823-B5EA-62CE86873502Q46082485-47DDA35E-A1EE-4674-B693-A6931017C5BCQ46418279-89CED20B-2E30-4988-AC04-07A80797B8F6Q46514701-930389FA-E24C-456F-9261-C506DABF5C87Q46957879-8B7EBF6A-4135-4BF2-83FE-C9818B07C2FDQ47698358-3FE5E174-F359-42B9-850D-DDC6E919421AQ53186365-9D703FA2-8A35-4D48-B2DB-B73FE354F2C1Q53404409-F45AC637-2DBB-455F-8F89-67DE5EB84AFEQ54278269-980C763D-A315-4F03-B6D4-6F4D5E9A675BQ57109274-B82B6208-2977-4E7A-8C63-8557FC827CA3
P2860
Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Assessment of chimeric mice wi ...... circulating human metabolites.
@en
Assessment of chimeric mice wi ...... circulating human metabolites.
@nl
type
label
Assessment of chimeric mice wi ...... circulating human metabolites.
@en
Assessment of chimeric mice wi ...... circulating human metabolites.
@nl
prefLabel
Assessment of chimeric mice wi ...... circulating human metabolites.
@en
Assessment of chimeric mice wi ...... circulating human metabolites.
@nl
P2093
P356
P1476
Assessment of chimeric mice wi ...... circulating human metabolites
@en
P2093
Akio Kawamura
Ayako Mera
Katsuhiro Suzuki
Kinya Souda
Kohichiro Tanaka
Naoyuki Nakada
Takafumi Iwatsubo
Takashi Usui
Yuichi Murakami
P304
P356
10.2133/DMPK.25.223
P577
2010-01-01T00:00:00Z