The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.
about
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNARole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesGenome sequencing and comparative genomics of the broad host-range pathogen Rhizoctonia solani AG8.TET enzymes, TDG and the dynamics of DNA demethylation.Synonymous codon usage bias is correlative to intron number and shows disequilibrium among exons in plants.Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase.Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.Synonymous Codon Usage Bias in the Plastid Genome is Unrelated to Gene Structure and Shows Evolutionary Heterogeneity.Synonymous codon usage bias in plant mitochondrial genes is associated with intron number and mirrors species evolution.DNA methylation dynamics in plants and mammals: overview of regulation and dysregulation.Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease.Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3AMutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA.Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms.Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNAFunctions and Malfunctions of Mammalian DNA-Cytosine DeaminasesMultiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease.Mechanisms of DNA damage, repair, and mutagenesis.Structural, electronic and energetic consequences of epigenetic cytosine modifications.Replacement of Thymidine by a Modified Base in the Escherichia coli GenomeAPOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.Replacement of 2'-Deoxycytidine by 2'-Deoxycytidine Analogues in the E. coli Genome.AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.On the Origin of the Canonical Nucleobases: An Assessment of Selection Pressures across Chemical and Early Biological Evolution.Refining the genetic alphabet: a late-period selection pressure?How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA.Dnmt2 methyltransferases and immunity: an ancient overlooked connection between nucleotide modification and host defense?Deamination features of 5-hydroxymethylcytosine, a radical and enzymatic DNA oxidation product.Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2'-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives.Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2'-deoxycytidine level in cultured cancerous cell lines.Reversible DNA-Protein Cross-Linking at Epigenetic DNA Marks.Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects.Computational study of the reactivity of cytosine derivatives.A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria.Harnessing natural DNA modifying activities for editing of the genome and epigenome.A simple but effective modeling strategy for structural properties of non-heme Fe(II) sites in proteins: test of force field models and application to proteins in the AlkB family.
P2860
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P2860
The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
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artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
The curious chemical biology o ...... dulators of genomic potential.
@en
The curious chemical biology o ...... dulators of genomic potential.
@nl
type
label
The curious chemical biology o ...... dulators of genomic potential.
@en
The curious chemical biology o ...... dulators of genomic potential.
@nl
prefLabel
The curious chemical biology o ...... dulators of genomic potential.
@en
The curious chemical biology o ...... dulators of genomic potential.
@nl
P2860
P356
P1433
P1476
The curious chemical biology o ...... odulators of genomic potential
@en
P2093
Christopher S Nabel
Sara A Manning
P2860
P356
10.1021/CB2002895
P577
2011-10-31T00:00:00Z